PDBsum entry 3po7

Oxidoreductase/oxidoreductase inhibitor

PDB id: 3po7

Contents

Protein chain

499 a.a.

Ligands

FAD ×2

ZON ×2

Waters ×749

References listed in PDB file

Key reference

• Title: Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase b complex.
• Authors: C.Binda, M.Aldeco, A.Mattevi, D.E.Edmondson.
• Ref.: J Med Chem, 2011, 54, 909-912.
• PubMed id: 21175212

Abstract

The binding of zonisamide to purified, recombinant monoamine oxidases (MAOs) has been investigated. It is a competitive inhibitor of human MAO B (K(i) = 3.1 ± 0.3 μM), of rat MAO B (K(i) = 2.9 ± 0.5 μM), and of zebrafish MAO (K(i) = 30.8 ± 5.3 μM). No inhibition is observed with purified human or rat MAO A. The 1.8 Å structure of the MAO B complex demonstrates that it binds within the substrate cavity.