PDBsum entry 3cc6

Transferase

PDB id: 3cc6

Contents

Protein chain

269 a.a. *

Ligands

GOL

Metals

_MG

Waters ×224

* Residue conservation analysis

PDB id:

3cc6

Name:

Transferase

Title:

Crystal structure of kinase domain of protein tyrosine kinase 2 beta (ptk2b)

Structure:

Protein tyrosine kinase 2 beta. Chain: a. Fragment: kinase domain: residues 414-692. Synonym: focal adhesion kinase 2, fadk 2, proline-rich tyrosine kinase 2, cell adhesion kinase beta, cak beta, calcium-dependent tyrosine kinase, cadtk, related adhesion focal tyrosine kinase, raftk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.60Å R-factor: 0.187 R-free: 0.219

Authors:

R.D.Busam,L.Lehtio,T.Karlberg,C.H.Arrowsmith,C.Bountra,R.Collins, L.G.Dahlgren,A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom, T.Helleday,M.D.Herman,A.Johansson,I.Johansson,A.Kallas,T.Kotenyova, M.Moche,M.E.Nilsson,P.Nordlund,T.Nyman,C.Persson,J.Sagemark, L.Svensson,A.G.Thorsell,L.Tresaugues,S.Van Den Berg,J.Weigelt, M.Welin,H.Berglund,Structural Genomics Consortium (Sgc)

Key ref:

R.D.Busam et al. Structure of protein tyrosine kinase 2 beta (ptk2b) kinase domain.. To be published, .

Date:

25-Feb-08 Release date: 11-Mar-08

Protein chain

Q14289  (FAK2_HUMAN) -  Protein-tyrosine kinase 2-beta from Homo sapiens

Seq: 1009 a.a.

Struc: 269 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site