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PDBsum entry 2j4a
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References listed in PDB file
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Key reference
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Title
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Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor.
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Authors
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K.Koehler,
S.Gordon,
P.Brandt,
B.Carlsson,
A.Bäcksbro-Saeidi,
T.Apelqvist,
P.Agback,
G.J.Grover,
W.Nelson,
M.Grynfarb,
M.Färnegårdh,
S.Rehnmark,
J.Malm.
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Ref.
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J Med Chem, 2006,
49,
6635-6637.
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PubMed id
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Abstract
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A new high-affinity thyroid hormone antagonist 6 with druglike properties was
designed and synthesized. The compound behaved as an antagonist in a cell
transactivation assay, and in a first in vivo experiment in rats.
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