PDBsum entry 2e54

Transferase

PDB id: 2e54

Contents

Protein chain

385 a.a. *

Ligands

PLP

EDO ×2

Metals

_NA ×2

Waters ×516

* Residue conservation analysis

PDB id:

2e54

Name:

Transferase

Title:

Crystal structure of acetylornithine aminotransferase from thermotoga maritima

Structure:

Acetylornithine aminotransferase. Chain: a. Synonym: acoat. Engineered: yes

Source:

Thermotoga maritima. Organism_taxid: 243274. Strain: msb8. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.50Å R-factor: 0.196 R-free: 0.213

Authors:

H.Mizutani,N.Kunishima,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

H.Mizutani and n.kunishima Crystal structure of acetylornithine aminotransferase from thermotoga maritima. To be published, .

Date:

19-Dec-06 Release date: 19-Jun-07

Protein chain

Q9X2A5  (ARGD_THEMA) -  Acetylornithine aminotransferase from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)

Seq: 385 a.a.

Struc: 385 a.a.

Enzyme reactions

• Enzyme class: E.C.2.6.1.11 - acetylornithine transaminase.
• Pathway: Ornithine Biosynthesis
• Reaction: N₂-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

N(2)-acetyl-L-ornithine (Bound ligand (Het Group name = EDO) matches with 40.00% similarity) + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

• Cofactor: Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate (Bound ligand (Het Group name = PLP) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site