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PDBsum entry 2cde
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Cell receptor
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PDB id
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2cde
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References listed in PDB file
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Key reference
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Title
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Structure and binding kinetics of three different human cd1d-Alpha-Galactosylceramide-Specific t cell receptors.
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Authors
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S.D.Gadola,
M.Koch,
J.Marles-Wright,
N.M.Lissin,
D.Shepherd,
G.Matulis,
K.Harlos,
P.M.Villiger,
D.I.Stuart,
B.K.Jakobsen,
V.Cerundolo,
E.Y.Jones.
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Ref.
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J Exp Med, 2006,
203,
699-710.
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PubMed id
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Abstract
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Invariant human TCR Valpha24-Jalpha18+/Vbeta11+ NKT cells (iNKT) are restricted
by CD1d-alpha-glycosylceramides. We analyzed crystal structures and binding
characteristics for an iNKT TCR plus two CD1d-alpha-GalCer-specific Vbeta11+
TCRs that use different TCR Valpha chains. The results were similar to those
previously reported for MHC-peptide-specific TCRs, illustrating the versatility
of the TCR platform. Docking TCR and CD1d-alpha-GalCer structures provided
plausible insights into their interaction. The model supports a diagonal
orientation of TCR on CD1d and suggests that complementarity determining region
(CDR)3alpha, CDR3beta, and CDR1beta interact with ligands presented by CD1d,
whereas CDR2beta binds to the CD1d alpha1 helix. This docking provides an
explanation for the dominant usage of Vbeta11 and Vbeta8.2 chains by human and
mouse iNKT cells, respectively, for recognition of CD1d-alpha-GalCer.
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