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PDBsum entry 1zph
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References listed in PDB file
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Key reference
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Title
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Structures of two minor-Groove-Binding quinolinium quaternary salts complexed with d(cgcgaattcgcg)(2) at 1.6 and 1.8 angstrom resolution.
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Authors
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A.Adams,
C.Leong,
W.A.Denny,
J.M.Guss.
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Ref.
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Acta Crystallogr D Biol Crystallogr, 2005,
61,
1348-1353.
[DOI no: ]
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PubMed id
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Abstract
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The structures of the complexes formed between two anticancer
minor-groove-binding quinolinium quaternary salts and the dodecamer
d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8 Angstrom. The
complexes crystallized in space group P2(1)2(1)2(1) and the structures are
isomorphous with previously solved dodecamer structures. The ligands both bind
in the central AT region of the minor groove and although the crystallization
conditions and structures of the ligands are very similar, they bind in opposing
orientations. The structures are compared with two previously published
structures of quinolinium quaternary salts, refined at 2.5 Angstrom resolution,
complexed with d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA.
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Figure 1.
Figure 1 Structure of the compounds.
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The above figure is
reprinted
by permission from the IUCr:
Acta Crystallogr D Biol Crystallogr
(2005,
61,
1348-1353)
copyright 2005.
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Headers
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