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PDBsum entry 1v1j
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References listed in PDB file
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Key reference
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Title
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(1r,4s,5r)-3-Fluoro-1,4,5-Trihydroxy-2-Cyclohexene-1-Carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type ii dehydroquinases.
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Authors
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M.Frederickson,
A.W.Roszak,
J.R.Coggins,
A.J.Lapthorn,
C.Abell.
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Ref.
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Org Biomol Chem, 2004,
2,
1592-1596.
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PubMed id
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Abstract
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The fluoro analogue of the enolate intermediate in the reaction catalyzed by
type II dehydroquinases has been prepared from naturally occurring (-)-quinic
acid over seven steps and has been shown to be the most potent inhibitor
reported to date of the type II enzyme from Mycobacterium tuberculosis.
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