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PDBsum entry 1tip
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crystal structure of a trapped phosphoenzyme during a catalytic reaction.
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Authors
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Y.H.Lee,
T.W.Olson,
C.M.Ogata,
D.G.Levitt,
L.J.Banaszak,
A.J.Lange.
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Ref.
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Nat Struct Biol, 1997,
4,
615-618.
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PubMed id
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Abstract
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The crystal structure of the fructose-2,6-bisphosphatase domain trapped during
the reaction reveal a phosphorylated His 258, and a water molecule immobilized
by the product, fructose-6-phosphate. The geometry suggests that the
dephosphorylation step requires prior removal of the product for an 'associative
in-line' phosphoryl transfer to the catalytic water.
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Secondary reference #1
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Title
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6-Phosphofructo-2-Kinase/fructose-2,6-Bisphosphatase: a metabolic signaling enzyme.
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Authors
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S.J.Pilkis,
T.H.Claus,
I.J.Kurland,
A.J.Lange.
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Ref.
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Annu Rev Biochem, 1995,
64,
799-835.
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PubMed id
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Secondary reference #2
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Title
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Preliminary X-Ray analysis of a truncated form of recombinant fructose-2,6-Bisphosphatase.
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Authors
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Y.H.Lee,
K.Lin,
D.Okar,
N.L.Alfano,
R.Sarma,
J.W.Pflugrath,
S.J.Pilkis.
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Ref.
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J Mol Biol, 1994,
235,
1147-1151.
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PubMed id
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