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PDBsum entry 1tcs
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Protein synthesis inhibitor
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PDB id
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1tcs
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References listed in PDB file
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Key reference
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Title
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Crystal structure of trichosanthin-Nadph complex at 1.7 a resolution reveals active-Site architecture.
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Authors
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J.P.Xiong,
Z.X.Xia,
Y.Wang.
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Ref.
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Nat Struct Biol, 1994,
1,
695-700.
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PubMed id
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Abstract
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We describe here the crystal structure of the trichosanthin-NADPH complex
determined at a resolution of 1.7 A. The adenine base stacks between Tyr 70 and
Tyr 111. Arg 163, Glu 160 and Tyr 70 form hydrogen bonds to N(3), O(3') and,
through a water molecule, to N(9) of adenosine, respectively. This is the first
high resolution structure of a complex between a ribosome-inactivating protein
and a substrate analogue, in which the electron density of the N-glycosidic bond
is well defined and the preassociated water, thought to be responsible for
hydrolyzing the N-C bond, is also explicitly elucidated.
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Secondary reference #1
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Title
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The three-Dimensional structure of trichosanthin refined at 2.7 angstroms resolution
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Authors
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Z.-X.Xia,
L.Zhang,
Z.-M.Zhang.
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Ref.
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chin j chem, 1993,
11,
280.
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Secondary reference #2
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Title
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The revision of three-Dimensional structure of trichosanthin at 3 angstroms resolution
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Authors
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Z.-X.Xia,
Z.-M.Zhang,
L.Zhang.
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Ref.
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chin j chem, 1991,
9,
563.
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