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PDBsum entry 1if3
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Virus/viral protein
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PDB id
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1if3
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References listed in PDB file
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Key reference
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Title
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Model for the structure of the HIV gp41 ectodomain: insight into the intermolecular interactions of the gp41 loop.
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Author
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M.Caffrey.
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Ref.
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Biochim Biophys Acta, 2001,
1536,
116-122.
[DOI no: ]
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PubMed id
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Note In the PDB file this reference is
annotated as "TO BE PUBLISHED".
The citation details given above were identified by an automated
search of PubMed on title and author
names, giving a
perfect match.
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Abstract
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In human immunodeficiency virus (HIV) the viral envelope proteins gp41 and gp120
form a non-covalent complex, which is a potential target for AIDS therapies. In
addition gp41 plays a possible role in HIV infection of B cells via the
complement system. In an effort to better understand the molecular interactions
of gp41, the structure of the HIV gp41 ectodomain has been modeled using the NMR
restraints of the simian immunodeficiency virus (SIV) gp41 ectodomain (M.
Caffrey, M. Cai, J. Kaufman, S.J. Stahl, P.T. Wingfield, A.M. Gronenborn, G.M.
Clore, Solution structure of the 44 kDa ectodomain of SIV gp41, EMBO J. 17
(1998) 4572--4584). The resulting model presents the first structural
information for the HIV gp41 loop, which has been implicated to play a direct
role in binding to gp120 and C1q of the complement system.
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