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PDBsum entry 1b86
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Oxygen transport
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PDB id
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1b86
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Human deoxyhaemoglobin-2,3-Diphosphoglycerate complex low-Salt structure at 2.5 a resolution.
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Authors
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V.Richard,
G.G.Dodson,
Y.Mauguen.
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Ref.
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J Mol Biol, 1993,
233,
270-274.
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PubMed id
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Abstract
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The haemoglobin-2,3-diphosphoglycerate complex structure has been solved at 2.5
A resolution using crystals grown from low-salt solutions. The results show some
important differences with the precedent haemoglobin-2,3-diphosphoglycerate
high-salt structure solved by Arnone. First, we observe a loss of symmetry in
the binding site, secondly both of the lysine residues 82 beta interact with
2,3-diphosphoglycerate at the same time, each making two contacts. This level of
interaction is in agreement with the functional behaviour of natural haemoglobin
mutants with mutations at the 2,3-diphosphoglycerate binding site.
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