Ligand clusters for UniProt code Q15910

Ligand clusters for Q15910: Histone-lysine N-methyltransferase EZH2 from Homo sapiens

		Top 6 (of 9) ligand clusters Cluster 1. 2 ligand types 3 ligands Cluster 2. 3 ligand types 5 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 1 ligand Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 18 ligands
Representative protein: 6wkrC

Structures

PDB		Schematic diagram
6wkrC
5hynA
5ls6A
5wg6A
6c23K
		more ...

Cluster 1 contains 2 ligand types

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Ligand		Description
		1. Ligand: ALA-ALA-ALA-ARG-LYS-PHE-ALA × 2 PDB codes: 6c23(K), 6c24(K).
		2. Ligand: THR-LYS-ALA-ALA-ARG-MET-SER-ALA-PRO × 1 PDB code: 5hyn(A).

Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: SAH × 3 S-Adenosyl-L-Homocysteine PDB codes: 5hyn(A), 6wkr(C), 7at8(A).
		2. Ligand: 74D × 1 1-[(1~{r})-1-[1-[2,2-Bis(fluoranyl)propyl]piperidin-4- Yl]ethyl]-~{N}-[(4-Methoxy-6-Methyl-2- Oxidanylidene- 3~{h}-Pyridin-3-Yl)methyl]-2-Methyl-Indole-3- Carboxamide PDB code: 5ls6(A).
		3. Ligand: A9G × 1 1-[(2s)-Butan-2-Yl]-N-[(4,6-Dimethyl-2-Oxo-1,2- Dihydropyridin-3-Yl)methyl]-3-Methyl-6-[6- (Piperazin- 1-Yl)pyridin-3-Yl]-1h-Indole-4-Carboxamide PDB code: 5wg6(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: LEU-GLN-ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER × 1 M3L=N-Trimethyllysine. PDB code: 5ls6(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5h14(C).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: SO4 × 1 Sulfate ion PDB code: 4mi5(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
_Zn		1. Metal: _ZN × 18 PDB codes: 4mi0(A), 4mi5(A), 5hyn(A), 5ls6(A), 5wg6(A), 7at8(A),