Ligand clusters for UniProt code P43405

Ligand clusters for P43405: Tyrosine-protein kinase SYK from Homo sapiens

		Top 6 (of 14) ligand clusters Cluster 1. 70 ligand types 80 ligands Cluster 2. 1 ligand type 2 ligands Cluster 3. 3 ligand types 5 ligands Cluster 4. 1 ligand type 1 ligand Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 1 ligand
Representative protein: 4fl2A

Structures

PDB		Schematic diagram
4fl2A
4fl3A
5cy3A
4yjuA
4i0tA
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Cluster 1 contains 70 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 8 glycerin Glycerol PDB codes: 3srv(A), 4rx7(A), 4rx8(A), 5lma(A), 5lmb(A).
_Mg		2. Metal: _MG × 2 PDB codes: 4fl2(A), 4fl3(A).
		3. Ligand: STI × 1 imatinib 4-(4-Methyl-Piperazin-1-Ylmethyl)-N-[4-Methyl-3-(4- Pyridin-3-Yl-Pyrimidin-2-Ylamino)-Phenyl]- Benzamide PDB code: 1xbb(A).
		4. Ligand: STU × 1 Staurosporine PDB code: 1xbc(A).
		5. Ligand: ANP × 3 Phosphoaminophosphonic acid-Adenylate ester PDB codes: 4fl1(A), 4fl2(A), 4fl3(A).
		6. Ligand: 057 × 1 N-(2-Hydroxy-1,1-Dimethylethyl)-1-Methyl-3-(1h- Pyrrolo[2,3-B]pyridin-2-Yl)-1h-Indole-5-Carboxamide PDB code: 3fqh(A).
		7. Ligand: 0JE × 1 3-[5-(5-Ethoxy-6-Fluoro-1h-Benzimidazol-2-Yl)-1h- Pyrazol-4-Yl]-1,1-Diethylurea PDB code: 3vf8(A).
		8. Ligand: 0K0 × 1 3-Amino-6-{3-[(Methylsulfonyl)amino]phenyl}-N- (Piperidin-4-Ylmethyl)pyrazine-2-Carboxamide PDB code: 4dfl(A).
		9. Ligand: 0K1 × 1 3-Amino-6-[3-(1-Methyl-1h-Pyrazol-4-Yl)phenyl]-N-[(1r, 2r,3s,5s,7s)-5-Hydroxyadamantan-2- Yl]pyrazine-2- Carboxamide PDB code: 4dfn(A).
		10. Ligand: 0SB × 1 N-{6-[3-(Piperazin-1-Yl)phenyl]pyridin-2-Yl}-4- (Trifluoromethyl)pyridin-2-Amine PDB code: 4f4p(A).
		11. Ligand: 0VE × 1 3-[8-({4-[Ethyl(2-Hydroxyethyl)amino]phenyl}amino) imidazo[1,2-A]pyrazin-5-Yl]phenol PDB code: 4fyn(A).
		12. Ligand: 0VF × 1 4-{[(3s)-1-{7-[(3,4-Dimethoxyphenyl)amino][1, 3]thiazolo[5,4-D]pyrimidin-5-Yl}pyrrolidin-3- Yl]carbamoyl}benzoic acid PDB code: 4fyo(A).
		13. Ligand: 0VG × 1 N-{6-[(2s)-2-Methylpyrrolidin-1-Yl]pyridin-2-Yl}-6- Phenylimidazo[1,2-B]pyridazin-8-Amine PDB code: 4fz6(A).
		14. Ligand: 0VH × 1 6-{[(1r,2s)-2-Aminocyclohexyl]amino}-4-[(6- Ethylpyridin-2-Yl)amino]pyridazine-3-Carboxamide PDB code: 4fz7(A).
		15. Ligand: 0XF × 1 6-{[(1r,2s)-2-Aminocyclohexyl]amino}-4-[(5,6- Dimethylpyridin-2-Yl)amino]pyridazine-3-Carboxamide PDB code: 4gfg(A).
		16. Ligand: 1B4 × 1 N-(Propan-2-Yl)-2-(3,4,5-Trimethoxyphenyl)-5h- Pyrrolo[2,3-B]pyrazine-7-Carboxamide PDB code: 4i0r(A).
		17. Ligand: 1B5 × 1 2-(6-Chloro-1-Methyl-1h-Indazol-3-Yl)-N-(Propan-2-Yl)- 5h-Pyrrolo[2,3-B]pyrazine-7-Carboxamide PDB code: 4i0s(A).
		18. Ligand: 1B6 × 1 N-Tert-Butyl-2-(5,6,7,8-Tetrahydroimidazo[1,5- A]pyridin-1-Yl)-5h-Pyrrolo[2,3-B]pyrazine-7- Carboxamide PDB code: 4i0t(A).
		19. Ligand: 2X6 × 1 7-{[(1r,2s)-2-Aminocyclohexyl]amino}-5-(1h-Indol-7- Ylamino)pyrido[4,3-D]pyrimidin-4(3h)-One PDB code: 4px6(A).
		20. Ligand: 3RT × 1 N~3~-(Tetrahydro-2h-Pyran-4-Yl)-N~6~-[5-(Tetrahydro-2h- Pyran-4-Ylmethyl)[1,2,4]triazolo[1,5- A]pyridin-2-Yl]- 1h-Indazole-3,6-Diamine PDB code: 4wnm(A).
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Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: ACE-THR-PTR-GLU-THR-LEU-NH2 × 2 ACE=Acetyl group, PTR=O-Phosphotyrosine, NH2=Amino group. PDB codes: 1csy(A), 1csz(A).

Cluster 3 contains 3 ligand types

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Ligand		Description
		1. Ligand: DMS × 2 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 4yjp(A), 6hm7(A).
		2. Ligand: GOL × 2 glycerin Glycerol PDB codes: 4yjo(A), 5lmb(A).
		3. Ligand: EDO × 1 Ethane-1,2-Diol PDB code: 4dfl(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3srv(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4rx9(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4yjt(A).