Ligand clusters for UniProt code P28223

Ligand clusters for P28223: 5-hydroxytryptamine receptor 2A from Homo sapiens

		Top 6 (of 10) ligand clusters Cluster 1. 8 ligand types 12 ligands Cluster 2. 2 ligand types 3 ligands Cluster 3. 2 ligand types 4 ligands Cluster 4. 2 ligand types 2 ligands Cluster 5. 1 ligand type 3 ligands Cluster 6. 1 ligand type 1 ligand
Representative protein: 6wh4A

Structures

PDB		Schematic diagram
6wh4A
6a94A
6a93A
6wgtA
6wgtB
		more ...

Cluster 1 contains 8 ligand types

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Ligand		Description
		1. Ligand: 8NU × 1 risperidone 3-[2-[4-(6-Fluoranyl-1,2-Benzoxazol-3-Yl)piperidin-1- Yl]ethyl]-2-Methyl-6,7,8,9- Tetrahydropyrido[1,2- A]pyrimidin-4-One PDB code: 6a93(A).
		2. Ligand: ZOT × 1 zotepine 2-(3-Chloranylbenzo[b][1]benzothiepin-5-Yl)oxy-N,N- Dimethyl-Ethanamine PDB code: 6a94(A).
		3. Ligand: PEG × 3 Di(hydroxyethyl)ether PDB codes: 6wgt(A), 6wh4(A),
		4. Ligand: 7LD × 2 (8alpha)-N,N-Diethyl-6-Methyl-9,10-Didehydroergoline-8- Carboxamide PDB codes: 6wgt(A),
		5. Ligand: 89F × 2 1-Methyl-4-[(5~{s})-3-Methylsulfanyl-5,6- Dihydrobenzo[b][1]benzothiepin-5-Yl]piperazine PDB codes: 6wh4(A),
		6. Ligand: 1PE × 1 Pentaethylene glycol PDB code: 6a93(A).
		7. Ligand: PO4 × 1 Phosphate ion PDB code: 6wgt(B).
		8. Ligand: U0G × 1 4-(2-{[(2-Hydroxyphenyl)methyl]amino}ethyl)-2,5- Dimethoxybenzonitrile PDB code: 6wha(A).

Cluster 2 contains 2 ligand types

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Ligand		Description
		1. Ligand: CLR × 1 cholesterol Cholesterol PDB code: 6wgt(A).
		2. Ligand: OLA × 2 Oleic acid PDB codes: 6wh4(A),

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: CLR × 1 cholesterol Cholesterol PDB code: 6wh4(A).
		2. Ligand: OLA × 3 Oleic acid PDB codes: 6wgt(A), 6wh4(B).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: PLM × 1 palmitic acid Palmitic acid PDB code: 6a93(A).
		2. Ligand: A6L × 1 2,3-Dihydroxypropyl (9z)-Octadec-9-Enoate PDB code: 6a94(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: CLR × 3 cholesterol Cholesterol PDB codes: 6a93(A), 6a94(A), 6wgt(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: OLA × 1 Oleic acid PDB code: 6wgt(A).