Ligand clusters for UniProt code P28062

Ligand clusters for P28062: Proteasome subunit beta type-8 from Homo sapiens

		3 ligand clusters Cluster 1. 13 ligand types 19 ligands Cluster 2. 2 ligand types 19 ligands Cluster 3. 1 ligand type 1 ligand
Representative protein: 5l5aK

Structures

PDB		Schematic diagram
5l5aK
5l5sK
5lttK
5l5hK
6e5bK
		more ...

Cluster 1 contains 13 ligand types

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Ligand		Description
		1. Ligand: 3BV × 1 carfilzomib N-{(2s)-2-[(Morpholin-4-Ylacetyl)amino]-4- Phenylbutanoyl}-L-Leucyl-N-[(2r,3s,4s)-1,3-Dihydroxy- 2,6-Dimethylheptan-4-Yl]-L-Phenylalaninamide PDB code: 5l5e(K).
		2. Ligand: BO2 × 1 bortezomib N-[(1r)-1-(Dihydroxyboryl)-3-Methylbutyl]-N-(Pyrazin-2- Ylcarbonyl)-L-Phenylalaninamide PDB code: 5l5f(K).
		3. Ligand: 39V × 3 N-[(3-Methyl-1h-Inden-2-Yl)carbonyl]-D-Alanyl-N-[(2s, 4r)-5-Hydroxy-4-Methyl-3-Oxo-1-Phenylpentan- 2-Yl]-L- Tryptophanamide PDB codes: 5l5h(K), 5l5s(K), 5ltt(K).
		4. Ligand: 04C × 2 1,2,4-Trideoxy-4-Methyl-2-{[N-(Morpholin-4-Ylacetyl)-L- Alanyl-O-Methyl-L-Tyrosyl]amino}-1-Phenyl- D-Xylitol PDB codes: 5l5d(K), 5l5u(K).
		5. Ligand: 6NV × 2 ~{N}-[(2~{r})-1-[[(2~{s})-3-(4-Methoxyphenyl)-1- [[(2~{s},3~{s},4~{r})-4-Methyl-3,5-Bis(oxidanyl)- 1- Phenyl-Pentan-2-Yl]amino]-1-Oxidanylidene-Propan-2- Yl]amino]-1-Oxidanylidene-Propan-2-Yl]-1- Methyl-5~{h}- Indene-2-Carboxamide PDB codes: 5l5q(K), 5l5v(K).
		6. Ligand: 79P × 2 (2~{s})-3-(1~{h}-Indol-3-Yl)-~{N}-[(2~{s},3~{s},4~{r})- 4-Methyl-3,5-Bis(oxidanyl)-1-Phenyl-Pentan- 2-Yl]-2- [[(2~{r})-2-(2-Morpholin-4-Ylethanoylamino) propanoyl]amino]propanamide PDB codes: 5l5o(K), 5l5t(K).
		7. Ligand: MES × 2 2-(N-Morpholino)-Ethanesulfonic acid PDB codes: 5l5p(K), 5ltt(K).
		8. Ligand: 38X × 1 N-[(3-Methyl-1h-Inden-2-Yl)carbonyl]-D-Alanyl-N-[(2s, 4r)-1-Cyclohexyl-5-Hydroxy-4-Methyl-3- Oxopentan-2-Yl]- L-Tryptophanamide PDB code: 5l5i(K).
		9. Ligand: 6N5 × 1 ~{N}-[(2~{s})-1-[[(2~{s})-3-(4-Methoxyphenyl)-1- [[(2~{s},3~{s},4~{r})-4-Methyl-3,5-Bis(oxidanyl)- 1- Phenyl-Pentan-2-Yl]amino]-1-Oxidanylidene-Propan-2- Yl]amino]-1-Oxidanylidene-Propan-2-Yl]-1- Methyl-5~{h}- Indene-2-Carboxamide PDB code: 5l5j(K).
		10. Ligand: 79L × 1 (2~{s})-3-(4-Methoxyphenyl)-~{N}-[(2~{s},3~{s},4~{r})- 4-Methyl-3,5-Bis(oxidanyl)-1-Phenyl-Pentan- 2-Yl]-2- [[(2~{r})-2-(2-Morpholin-4-Ylethanoylamino) propanoyl]amino]propanamide PDB code: 5l5p(K).
		11. Ligand: 7DX × 1 (2~{s})-2-Cyclohexyl-4-Oxidanylidene-4-[[7-(4-Phenyl-1, 3-Thiazol-2-Yl)quinolin-2- Yl]amino]butanoic acid PDB code: 5m2b(K).
		12. Ligand: BZ7 × 1 N~1~-{2-[([1,1'-Biphenyl]-3-Carbonyl)amino]ethyl}-N~4~- Tert-Butyl-N~2~-(3-Phenylpropanoyl)-L- Aspartamide PDB code: 6avo(C).
		13. Ligand: HUJ × 1 [(1r)-3-Methyl-1-[[1-[2-[(2,3,4-Trimethoxyphenyl) carbonylamino]ethyl]-1,2,3-Triazol-4- Yl]carbonylamino]butyl]-Tris(oxidanyl)boron PDB code: 6e5b(K).

Cluster 2 contains 2 ligand types

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Ligand		Description
_Mg		1. Metal: _MG × 18 PDB codes: 5l5a(K), 5l5b(K), 5l5d(K), 5l5e(K), 5l5f(K), 5l5h(K), 5l5i(K), 5l5j(K), 5l5o(K), 5l5p(K), 5l5q(K), 5l5r(K), 5l5s(K), 5l5t(K), 5l5u(K), 5l5v(K), 5ltt(K), 5m2b(K).
_Na		2. Metal: _NA × 1 PDB code: 6e5b(K).

Cluster 3 contains 1 ligand type

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Ligand		Description
_Mg		1. Metal: _MG × 1 PDB code: 5l5a(K).