Ligand clusters for UniProt code P17109

Ligand clusters for P17109: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase from Escherichia coli (strain K12)

		Top 6 (of 20) ligand clusters Cluster 1. 9 ligand types 31 ligands Cluster 2. 5 ligand types 15 ligands Cluster 3. 2 ligand types 3 ligands Cluster 4. 2 ligand types 2 ligands Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 7 ligands
Representative protein: 2jlaA

Structures

PDB		Schematic diagram
2jlaA
5ej5A
5z2pA
5z2uA
2jlcA
		more ...

Cluster 1 contains 9 ligand types

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Ligand		Description
_Mn		1. Metal: _MN × 10 PDB codes: 2jla(A), 2jlc(A), 5ej4(A), 5ej5(A), 5ej6(A), 5ej7(A), 5ej9(A), 5eja(A), 5ejm(A), 5z2p(A).
_Mg		2. Metal: _MG × 4 PDB codes: 3hww(A), 3hwx(A), 5z2r(A), 5z2u(A).
		3. Ligand: GOL × 1 glycerin Glycerol PDB code: 3hww(A).
		4. Ligand: TD6 × 8 (4s)-4-{3-[(4-Amino-2-Methylpyrimidin-5-Yl)methyl]-5- (2-{[(S)- Hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4- Methyl-1,3lambda~5~-Thiazol-2-Yl}-4- Hydroxybutanoic acid PDB codes: 5ej4(A), 5ej5(A), 5ej6(A), 5ej7(A), 5eja(A), 5z2p(A), 5z2r(A), 5z2u(A).
		5. Ligand: TPP × 4 Thiamine diphosphate PDB codes: 2jla(A), 2jlc(A), 3hwx(A), 5ej9(A).
		6. Ligand: AKG × 1 2-Oxoglutaric acid PDB code: 3hww(A).
		7. Ligand: TD5 × 1 (4~{r})-4-[3-[(4-Azanyl-2-Methyl-Pyrimidin-5-Yl) methyl]-4-Methyl-5-[2- [Oxidanyl(phosphonooxy) phosphoryl]oxyethyl]-1,3-Thiazol-3-Ium-2-Yl]-4- Oxidanyl-Butanoic acid PDB code: 5ejm(A).
_Cl		8. Metal: _CL × 1 PDB code: 2jla(A).
_Na		9. Metal: _NA × 1 PDB code: 3hww(A).

Cluster 2 contains 5 ligand types

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Ligand		Description
		1. Ligand: TD6 × 8 (4s)-4-{3-[(4-Amino-2-Methylpyrimidin-5-Yl)methyl]-5- (2-{[(S)- Hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4- Methyl-1,3lambda~5~-Thiazol-2-Yl}-4- Hydroxybutanoic acid PDB codes: 5ej4(A), 5ej5(A), 5ej6(A), 5ej7(A), 5eja(A), 5z2p(A), 5z2r(A), 5z2u(A).
		2. Ligand: TPP × 4 Thiamine diphosphate PDB codes: 2jla(A), 2jlc(A), 3hwx(A), 5ej9(A).
		3. Ligand: TD5 × 1 (4~{r})-4-[3-[(4-Azanyl-2-Methyl-Pyrimidin-5-Yl) methyl]-4-Methyl-5-[2- [Oxidanyl(phosphonooxy) phosphoryl]oxyethyl]-1,3-Thiazol-3-Ium-2-Yl]-4- Oxidanyl-Butanoic acid PDB code: 5ejm(A).
_Cl		4. Metal: _CL × 1 PDB code: 2jla(A).
_Na		5. Metal: _NA × 1 PDB code: 3hww(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 5ej4(A), 5ej7(A).
		2. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5ejm(A).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3hww(A).
_Na		2. Metal: _NA × 1 PDB code: 3hww(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3hww(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 7 glycerin Glycerol PDB codes: 5ej4(A), 5ej5(A), 5ej7(A), 5ej9(A), 5eja(A), 5ejm(A), 5z2r(A).