Ligand clusters for UniProt code P16184

Ligand clusters for P16184: Dihydrofolate reductase from Pneumocystis carinii

		2 ligand clusters Cluster 1. 27 ligand types 52 ligands Cluster 2. 1 ligand type 1 ligand
Representative protein: 1cd2A

Structures

PDB		Schematic diagram
1cd2A
3cd2A
1dyrA
2fzhA
1ly4A
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Cluster 1 contains 27 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: NDP × 4 Nadph dihydro-Nicotinamide-Adenine-Dinucleotide phosphate PDB codes: 1daj(A), 1dyr(A), 1klk(A), 1vj3(A).
		2. Ligand: NAP × 7 Nadp nicotinamide-Adenine-Dinucleotide phosphate PDB codes: 1cd2(A), 1e26(A), 1ly3(A), 1ly4(A), 1s3y(A), 2cd2(A), 3cd2(A).
		3. Ligand: FOL × 3 folic acid Folic acid PDB codes: 1cd2(A), 2cd2(A), 4cd2(A).
		4. Ligand: TOP × 2 trimethoprim Trimethoprim PDB codes: 1dyr(A), 4g8z(X).
		5. Ligand: GOL × 1 glycerin Glycerol PDB code: 3nzc(X).
		6. Ligand: MTX × 1 Methotrexate PDB code: 3cd2(A).
		7. Ligand: MOT × 1 N-[4-[(2,4-Diaminofuro[2,3d]pyrimidin-5-Yl) methyl]methylamino]-Benzoyl]-L-Glutamate PDB code: 1daj(A).
		8. Ligand: GPB × 1 N-[4-[2-(2-Amino-4-Methyl-7h-Pyrrolo[2,3-D]pyrimidin-5- Yl)-Ethyl]-Benzoyl]glutamic acid PDB code: 1e26(A).
		9. Ligand: PMD × 1 [N-(2,4-Diaminopteridin-6-Yl)-Methyl]-Dibenz[b, F]azepine PDB code: 1klk(A).
		10. Ligand: COG × 1 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N- Methylamino]quinazoline PDB code: 1ly3(A).
		11. Ligand: TAB × 1 Acetic acid n-[2-Chloro-5-[6-Ethyl-2,4-Diamino-Pyrimid- 5-Yl]-Phenyl]-[Benzyl-Triazen-3- Yl]ethyl ester PDB code: 1vj3(A).
		12. Ligand: COQ × 1 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N- Methylamino]pyrido[2,3-D]pyrimidine PDB code: 1ly4(A).
		13. Ligand: TQT × 1 6-(Octahydro-1h-Indol-1-Ylmethyl)decahydroquinazoline- 2,4-Diamine PDB code: 1s3y(A).
		14. Ligand: DH1 × 1 2,4-Diamino-5-[2-Methoxy-5-(4-Carboxybutyloxy) benzyl]pyrimidine PDB code: 2fzh(A).
		15. Ligand: DH3 × 1 2,4-Diamino-5-[3',4'-Dimethoxy-5'-(5-Carboxyl-1- Pentynyl)]benzyl pyrimidine PDB code: 2fzi(A).
		16. Ligand: NDP × 12 Nadph dihydro-Nicotinamide-Adenine-Dinucleotide phosphate PDB codes: 2fzh(A), 2fzi(A), 3nz6(X), 3nz9(X), 3nza(X), 3nzb(X), 3td8(A), 4g8z(X), 4ixe(D), 4ixf(X), 4ixg(X), 4qjz(D).
		17. Ligand: D2K × 2 Ethyl 4-{3-[(2,4-Diamino-5-Methylpyrido[2,3- D]pyrimidin-6-Yl)methyl]-4-Methoxyphenoxy}butanoate PDB codes: 3nz9(X), 3nza(X).
		18. Ligand: D2N × 2 Ethyl 6-{3-[(2,4-Diamino-5-Methylpyrido[2,3- D]pyrimidin-6-Yl)methyl]-4-Methoxyphenoxy}hexanoate PDB codes: 3nzb(X),
		19. Ligand: 33M × 1 N~6~-Methyl-N~6~-(Naphthalen-1-Yl)pyrido[2,3- D]pyrimidine-2,4,6-Triamine PDB code: 4qjz(D).
		20. Ligand: D2J × 1 6-{3-[(2,4-Diamino-5-Methylpyrido[2,3-D]pyrimidin-6- Yl)methyl]-4-Methoxyphenoxy}hexanoic acid PDB code: 3nz6(X).
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Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3nzc(X).