Ligand clusters for UniProt code P08631

Ligand clusters for P08631: Tyrosine-protein kinase HCK OS=Homo sapiens OX=9606 GN=HCK PE=1 SV=5

		Top 6 (of 7) ligand clusters Cluster 1. 25 ligand types 29 ligands Cluster 2. 1 ligand type 1 ligand Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 1 ligand Cluster 5. 1 ligand type 17 ligands Cluster 6. 1 ligand type 16 ligands
Representative protein: 1qcfA

Structures

PDB		Schematic diagram
1qcfA
3vrzA
2c0oA
2c0tA
3vs0A
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Cluster 1 contains 25 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 4lue(A),
		2. Ligand: ANP × 1 Phosphoaminophosphonic acid-Adenylate ester PDB code: 1ad5(A).
		3. Ligand: QUE × 1 3,5,7,3',4'-Pentahydroxyflavone PDB code: 2hck(A).
		4. Ligand: PP1 × 1 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]pyrimidin-4- Ylamine PDB code: 1qcf(A).
		5. Ligand: L1G × 1 N-(4-{4-Amino-1-[4-(4-Methylpiperazin-1-Yl)-Trans- Cyclohexyl]-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl}-2- Methoxyphenyl)-1-Methyl-1h-Indole-2-Carboxamide PDB code: 2c0i(A).
		6. Ligand: L2G × 1 N-(4-{1-[4-(4-Acetylpiperazin-1-Yl)-Trans-Cyclohexyl]- 4-Amino-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl}-2- Methoxyphenyl)-1-Methyl-1h-Indole-2-Carboxamide PDB code: 2c0o(A).
		7. Ligand: L3G × 1 N-(4-{4-Amino-1-[1-(Tetrahydro-2h-Pyran-4-Yl)piperidin- 4-Yl]-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl}-2- Methoxyphenyl)-1-Methyl-1h-Indole-2-Carboxamide PDB code: 2c0t(A).
		8. Ligand: VSE × 3 7-[Trans-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4- Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4- Amine PDB codes: 3vs3(A), 4lue(A), 5zj6(A).
_Ca		9. Metal: _CA × 2 PDB codes: 1ad5(A), 2c0t(A).
		10. Ligand: 1BM × 1 3-{[2-(1h-Benzimidazol-1-Yl)-6-{[2-(Diethylamino) ethyl]amino}pyrimidin-4-Yl]amino}-4-Methylphenol PDB code: 2hk5(A).
		11. Ligand: B43 × 1 4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin- 7-Yl-Cyclopentane PDB code: 3vry(A).
		12. Ligand: KS1 × 1 1-Cyclopentyl-3-(1h-Pyrrolo[2,3-B]pyridin-5-Yl)-1h- Pyrazolo[3,4-D]pyrimidin-4-Amine PDB code: 3vs7(A).
		13. Ligand: OOO × 1 Ethyl (2~{s})-2-[[4-[4-Azanyl-5-(4-Phenoxyphenyl) pyrrolo[2,3-D]pyrimidin-7-Yl]cyclohexyl]amino]-4- Methyl-Pentanoate PDB code: 5h09(A).
		14. Ligand: OOQ × 1 (2~{s})-2-[[4-[4-Azanyl-5-(4-Phenoxyphenyl)pyrrolo[2,3- D]pyrimidin-7-Yl]cyclohexyl]azaniumyl]-4- Methyl- Pentanoate PDB code: 5h0b(A).
		15. Ligand: OOS × 1 (2~{s})-2-[[4-[4-Azanyl-5-(4-Phenoxyphenyl)pyrrolo[2,3- D]pyrimidin-7-Yl]cyclohexyl]amino]-4- Methyl- Pentanamide PDB code: 5h0e(A).
		16. Ligand: OOU × 1 (2~{s})-2-[[4-[4-Azanyl-5-(4-Phenoxyphenyl)pyrrolo[2,3- D]pyrimidin-7-Yl]cyclohexyl]amino]-~{N},4- Dimethyl- Pentanamide PDB code: 5h0g(A).
		17. Ligand: OOV × 1 (2~{s})-2-[[4-[4-Azanyl-5-(4-Phenoxyphenyl)pyrrolo[2,3- D]pyrimidin-7-Yl]cyclohexyl]amino]- ~{N},~{N},4- Trimethyl-Pentanamide PDB code: 5h0h(A).
		18. Ligand: SK8 × 1 6-(4-Fluorophenyl)-5-(Pyridin-4-Yl)-2,3- Dihydroimidazo[2,1-B][1,3]thiazole PDB code: 4lud(A).
		19. Ligand: VRZ × 1 1-[4-(4-Amino-7-Cyclopentyl-7h-Pyrrolo[2,3-D]pyrimidin- 5-Yl)phenyl]-3-Benzylurea PDB code: 3vrz(A).
		20. Ligand: VS0 × 1 N-[4-(4-Amino-7-Cyclopentyl-7h-Pyrrolo[2,3-D]pyrimidin- 5-Yl)phenyl]benzamide PDB code: 3vs0(A).
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Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: MPD × 1 (4s)-2-Methyl-2,4-Pentanediol PDB code: 4u5w(B).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: MPD × 1 (4s)-2-Methyl-2,4-Pentanediol PDB code: 4u5w(B).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4lud(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
_Ca		1. Metal: _CA × 17 PDB codes: 1ad5(A), 2c0i(A), 2c0o(A), 2c0t(A), 2hck(A), 3vry(A), 3vrz(A), 3vs0(A), 3vs1(A), 3vs2(A), 3vs3(A), 3vs4(A), 3vs5(A), 3vs6(A), 3vs7(A), 4lud(A), 4lue(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
_Ca		1. Metal: _CA × 16 PDB codes: 1ad5(A), 2c0i(A), 2c0o(A), 2c0t(A), 2hck(A), 3vry(A), 3vs0(A), 3vs1(A), 3vs2(A), 3vs3(A), 3vs4(A), 3vs5(A), 3vs6(A), 3vs7(A), 4lud(A), 4lue(A).