Ligand clusters for UniProt code O75530

Ligand clusters for O75530: Polycomb protein EED from Homo sapiens

		Top 6 (of 11) ligand clusters Cluster 1. 37 ligand types 41 ligands Cluster 2. 3 ligand types 3 ligands Cluster 3. 2 ligand types 3 ligands Cluster 4. 2 ligand types 2 ligands Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 1 ligand
Representative protein: 5wukA

Structures

PDB		Schematic diagram
5wukA
6yvjA
6sfbA
5ij7E
5h15A
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Cluster 1 contains 37 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5wuk(A).
		2. Ligand: L9W × 3 ~{N}-(1-Benzofuran-4-Ylmethyl)-8-(4- Methylsulfonylphenyl)-[1,2,4]triazolo[4,3-C]pyrimidin- 5- Amine PDB codes: 6sfc(A), 6yvi(A), 6yvj(A).
		3. Ligand: 73K × 2 N-(Furan-2-Ylmethyl)-8-(4-Methylsulfonylphenyl)-[1,2, 4]triazolo[4,3-C]pyrimidin-5-Amine PDB codes: 5gsa(A), 5wuk(A).
		4. Ligand: LQD × 2 (3r,4s)-1-[(2-Methoxyphenyl)methyl]-N,N-Dimethyl-4-(1- Methylindol-3-Yl)pyrrolidin-3-Amine PDB codes: 5h15(A), 5u69(A).
		5. Ligand: 6PU × 1 (3r,4s)-1-[(1s)-7-Fluoro-2,3-Dihydro-1h-Inden-1-Yl]-N, N-Dimethyl-4-{4-[4- (Methylsulfonyl)piperazin-1- Yl]phenyl}pyrrolidin-3-Amine PDB code: 5k0m(A).
		6. Ligand: 7VV × 1 (6s)-6-[(2-Fluoro-5-Methoxyphenyl)methyl]-1-(Propan-2- Yl)-5,6,7,8-Tetrahydroimidazo[1,5-A]pyridin- 3-Amine PDB code: 5u5h(A).
		7. Ligand: 7VY × 1 (3r)-3-[(3-Methoxyphenyl)methyl]piperidine PDB code: 5u5k(A).
		8. Ligand: 7W7 × 1 (3r)-3-[(2h-1,3-Benzodioxol-4-Yl)methyl]piperidine-1- Carboximidamide PDB code: 5u5t(A).
		9. Ligand: 7WD × 1 (6s)-6-[(2h-1,3-Benzodioxol-4-Yl)methyl]-5,6,7,8- Tetrahydroimidazo[1,5-A]pyridin-3-Amine PDB code: 5u62(A).
		10. Ligand: 7XG × 1 2-[4-(4-{(3s,4r)-4-(Dimethylamino)-1-[(2-Fluoro-6- Methylphenyl)methyl]pyrrolidin-3-Yl}phenyl)-1h- Pyrazol-1-Yl]acetamide PDB code: 5u6d(A).
		11. Ligand: 82D × 1 (3r,4s)-1-[(2-Bromo-6-Fluorophenyl)methyl]-N,N- Dimethyl-4-(1-Methyl-1h-Indol-3-Yl)pyrrolidin-3- Amine PDB code: 5u8a(A).
		12. Ligand: 82G × 1 (3r,4s)-1-[(1s)-7-Fluoro-2,3-Dihydro-1h-Inden-1-Yl]-N, N-Dimethyl-4-(1-Methyl-1h-Indol-3- Yl)pyrrolidin-3- Amine PDB code: 5u8f(A).
		13. Ligand: ALA-ARG-M3L-SER × 1 M3L=N-Trimethyllysine. PDB code: 3jzg(A).
		14. Ligand: ALA-ARG-M3L-SER-ALA × 1 M3L=N-Trimethyllysine. PDB code: 3iiw(A).
		15. Ligand: ALA-ARG-M3L-SER-ALA-GLY-ALA-ALA × 1 M3L=N-Trimethyllysine. PDB code: 3iiy(A).
		16. Ligand: ALA-ARG-M3L-SER-THR × 1 M3L=N-Trimethyllysine. PDB code: 3ij0(A).
		17. Ligand: ALA-GLN-ARG-M3L-PHE-ALA-GLN × 1 M3L=N-Trimethyllysine. PDB code: 6c24(L).
		18. Ligand: ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER × 1 M3L=N-Trimethyllysine. PDB code: 4x3e(A).
		19. Ligand: ARG-HIS-ARG-M3L-VAL-LEU-ARG × 1 M3L=N-Trimethyllysine. PDB code: 3ij1(A).
		20. Ligand: ASP-PHE-M3L-THR-ASP × 1 M3L=N-Trimethyllysine. PDB code: 3jzh(A).
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Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5h14(A).
		2. Ligand: Q3A × 1 8-(2,6-Dimethylpyridin-3-Yl)-N-[(5-Fluoro-2,3-Dihydro- 1-Benzofuran-4-Yl)methyl]-1- (Methylsulfonyl)imidazo[1, 5-C]pyrimidin-5-Amine PDB code: 6w7g(A).
		3. Ligand: Q3D × 1 8-(6-Cyclopropylpyridin-3-Yl)-N-[(5-Fluoro-2,3-Dihydro- 1-Benzofuran-4-Yl)methyl]-1- (Methylsulfonyl)imidazo[1, 5-C]pyrimidin-5-Amine PDB code: 6w7f(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: 6BN × 2 5,8-Dichloro-2-[(4-Ethyl-6-Methyl-2-Oxo-1,2- Dihydropyridin-3-Yl)methyl]-7-({1-[(2r)-2- Hydroxypropanoyl]piperidin-4-Yl}oxy)-3,4- Dihydroisoquinolin-1(2h)-One PDB codes: 5ij7(E), 5ij8(E).
		2. Ligand: 74D × 1 1-[(1~{r})-1-[1-[2,2-Bis(fluoranyl)propyl]piperidin-4- Yl]ethyl]-~{N}-[(4-Methoxy-6-Methyl-2- Oxidanylidene- 3~{h}-Pyridin-3-Yl)methyl]-2-Methyl-Indole-3- Carboxamide PDB code: 5ls6(B).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5h13(A).
		2. Ligand: XB7 × 1 astemizole 1-[(4-Fluorophenyl)methyl]-N-{1-[2-(4-Methoxyphenyl) ethyl]piperidin-4-Yl}-1h-Benzimidazol-2-Amine PDB code: 7kxt(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: Q3A × 1 8-(2,6-Dimethylpyridin-3-Yl)-N-[(5-Fluoro-2,3-Dihydro- 1-Benzofuran-4-Yl)methyl]-1- (Methylsulfonyl)imidazo[1, 5-C]pyrimidin-5-Amine PDB code: 6w7g(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5u5h(A).