Ligand clusters for UniProt code O00329

Ligand clusters for O00329: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform from Homo sapiens

		3 ligand clusters Cluster 1. 12 ligand types 12 ligands Cluster 2. 1 ligand type 1 ligand Cluster 3. 1 ligand type 1 ligand
Representative protein: 7lm2A

Structures

PDB		Schematic diagram
7lm2A
5t8fA
5dxuA
6ocoA
5m6uA
		more ...

Cluster 1 contains 12 ligand types

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Ligand		Description
		1. Ligand: 5H5 × 1 (2s)-2-({2-[1-(Propan-2-Yl)-1h-1,2,4-Triazol-5-Yl]-5,6- Dihydroimidazo[1,2-D][1,4]benzoxazepin-9- Yl}oxy) propanamide PDB code: 5dxu(A).
		2. Ligand: 799 × 1 2-Methyl-2-(4-{2-[3-Methyl-1-(Propan-2-Yl)-1h-1,2,4- Triazol-5-Yl]-5,6-Dihydroimidazo[1,2- D][1, 4]benzoxazepin-9-Yl}-1h-Pyrazol-1-Yl)propanamide PDB code: 5t8f(A).
		3. Ligand: 7KA × 1 4-Azanyl-6-[[(1~{s})-1-(4-Oxidanylidene-3-Phenyl- Pyrrolo[2,1-F][1,2,4]triazin-2- Yl) ethyl]amino]pyrimidine-5-Carbonitrile PDB code: 5m6u(A).
		4. Ligand: 85S × 1 1-[4-(3-{4-Amino-5-[1-(Oxan-4-Yl)-1h-Pyrazol-5- Yl]pyrrolo[2,1-F][1,2,4]triazin-7- Yl}phenyl)piperazin- 1-Yl]ethan-1-One PDB code: 5ubt(A).
		5. Ligand: 9EM × 1 4-Acetyl-1-(3-{4-Amino-5-[1-(2,2,2-Trifluoroethyl)-1h- Pyrazol-5-Yl]pyrrolo[2,1-F][1,2,4]triazin-7- Yl}phenyl)-3,3-Dimethylpiperazin-2-One PDB code: 5vlr(A).
		6. Ligand: EO5 × 1 ~{N}-[3-[4-[[(1~{s})-1-(5-Methyl-4-Oxidanylidene-3- Phenyl-Pyrrolo[2,1-F][1,2,4]triazin-2- Yl)ethyl]amino]- 7~{h}-Pyrrolo[2,3-D]pyrimidin-5-Yl]-5-Oxidanyl- Phenyl]methanesulfonamide PDB code: 6g6w(A).
		7. Ligand: M5D × 1 5-{(3r)-3-Methyl-4-[(1r,2r)-2-Methylcyclopropane-1- Carbonyl]piperazin-1-Yl}-3-(1-Methyl-1h- Pyrazol-4-Yl) pyrazine-2-Carbonitrile PDB code: 6ocu(A).
		8. Ligand: M5V × 1 4-[(1s,4s)-5-(3-Chlorophenyl)-2,5- Diazabicyclo[2.2.1]heptan-2-Yl]-2-(Pyridin-3-Yl) pyrimidine-5- Carbonitrile PDB code: 6oco(A).
		9. Ligand: P5J × 1 (3s)-3-Benzyl-3-Methyl-5-[5-(2-Methylpyrimidin-5-Yl) pyrazolo[1,5-A]pyrimidin-3-Yl]-1,3-Dihydro-2h- Indol-2- One PDB code: 6pyr(A).
		10. Ligand: P5V × 1 (3s)-1'-(Cyclopropanecarbonyl)-5-(Quinoxalin-6-Yl) spiro[indole-3,2'-Pyrrolidin]-2(1h)-One PDB code: 6pyu(A).
		11. Ligand: VBS × 1 (3s)-3-Benzyl-5-[9-Ethyl-8-(2-Methylpyrimidin-5-Yl)-9h- Purin-6-Yl]-3-Methyl-1,3-Dihydro-2h-Indol- 2-One PDB code: 7jis(A).
		12. Ligand: Y5Y × 1 Cyclopropyl[(3s)-3-{[9-Ethyl-8-(2-Methylpyrimidin-5- Yl)-9h-Purin-6-Yl]amino}pyrrolidin-1- Yl]methanone PDB code: 7lm2(A).

Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: SO4 × 1 Sulfate ion PDB code: 7lm2(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: EDO × 1 1,2-Ethanediol PDB code: 7lm2(A).