The enzyme catalyzes the synthesis of anthranilate from chorismate and glutamine and is feedback-inhibited by tryptophan. It binds a magnesium ion PMID10449718.
CATALYTIC METAL(S)
| Metal/Site Information | |||||
| Residue in MACiE* | Atom in MACiE* | Residue Type in MACiE | Physiological Metal |
Site Type |
Function(s) |
| none | none | magnesium | magnesium | mononuclear | Coordinates substrate Electrostatic stabiliser |
*It refers to the MACiE reference pdb: 1qdl
| Metal/s Properties in Resting State | ||||||
| none | Resting state enzyme (-) | |||||
| Oxidation State | 2 | |||||
| Coordination Geometry | unknownGeometry | |||||
| Coordination Number | unknown | |||||
| Notes | - | |||||
| References |
| -Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6021-6.(MEDLINE:11371633) |