The enzyme catalizes the formation of CDP-glycerol, which is used for the assembly of linkages between peptidoglycan and teichoic acid polymer in Gram-positive bacteria. It uses a magnesium ion for catalysis PMID 16344011.
DETAILS ON METAL
Not available |
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| Kinetic studies have shown the divalent magnesium ion to be essential for catalysis. However, at the moment no magnesium ion is present in the available structures, but it was suggested that the ion coordinates between the alpha phosphate of the CTP and the attacking phosphate of glycerol-3-phosphate PMID14506262. |
| Site type | Physiological Metal |
| mononuclear | magnesium |
| Metal in the Resting State | |||
| Oxidation State |
Coordination Geometry | Coordination Number | PDB |
| 2 | unknownGeometry | unknown | - |
| Metal in the reaction stages | ||||||
| Step | Metal function(s) | Initial-Final Oxid. states | Initial-Final Geometry | Initial-Final Coord. # | Initial PDB | Final PDB |
| Step 1 | Coordinates substrate Increases electrophilicity Electrostatic stabiliser |
+2 - +2 |
octahedral - octahedral |
6 - 6 | - | - |
* N.B. There may be steps that are not described in between two annotated steps. Consequently the product species of step n may differ from the reagent species of step n+1.