The enzyme catalizes the formation of CDP-glycerol, which is used for the assembly of linkages between peptidoglycan and teichoic acid polymer in Gram-positive bacteria. It uses a magnesium ion for catalysis PMID 16344011.
CATALYTIC METAL(S)
| Metal/Site Information | |||||
| Residue in MACiE* | Atom in MACiE* | Residue Type in MACiE | Physiological Metal |
Site Type |
Function(s) |
| none | none | magnesium | magnesium | mononuclear | Coordinates substrate Increases electrophilicity Electrostatic stabiliser |
*It refers to the MACiE reference pdb: 1n1d
| Metal/s Properties in Resting State | ||||||
| none | Resting state enzyme (-) | |||||
| Oxidation State | 2 | |||||
| Coordination Geometry | unknownGeometry | |||||
| Coordination Number | unknown | |||||
| Notes | - | |||||
| References |
| -Pattridge KA, Weber CH, Friesen JA, Sanker S, Kent C, Ludwig ML Glycerol-3-phosphate cytidylyltransferase. Structural changes induced by binding of CDP-glycerol and the role of lysine residues in catalysis. J Biol Chem. 2003 Dec 19;278(51):51863-71. Epub 2003 Sep 23.(MEDLINE:14506262) |