The enzyme catalyzes the interconversion of l-ribulose 5-phosphate and d-xylulose 5-phosphate. It binds a catalytic zinc ion which directly involved in the reaction mechanism (PMID11732895)
CATALYTIC METAL(S)
| Metal/Site Information | |||||
| Residue in MACiE* | Atom in MACiE* | Residue Type in MACiE | Physiological Metal |
Site Type |
Function(s) |
| ZN 301 A | ZN | zinc | zinc | mononuclear | Coordinates substrate Promotes heterolysis Increases electrophilicity Increases acidity |
*It refers to the MACiE reference pdb: 1jdi
| Metal/s Properties in Resting State | ||||||
| ZN 301 A | Resting state enzyme (1k0w) | |||||
| Oxidation State | 2 | |||||
| Coordination Geometry | tetrahedral | |||||
| Coordination Number | 4 | |||||
| Notes | - | |||||
| References |
| -Luo Y, Morgan PM, Strynadka NC, Tanner ME Catalysis and binding in L-ribulose-5-phosphate 4-epimerase: a comparison with L-fuculose-1-phosphate aldolase. Biochemistry. 2001 Dec 11;40(49):14772-80.(MEDLINE:11732896) |
| - Some information have been also deduced from the MACiE mechanism model |