CATALYTIC METALS IN STEP 2
| Metal/s Properties in step 2* | ||||||
| ZN 262 _ | Substrate-bound (1ca2) | Product-bound (1ca3) | ||||
| Oxidation State | 2 | 2 | ||||
| Coordination Geometry | tetrahedral | tetrahedral | ||||
| Coordination Number | 4 | 4 | ||||
| Notes on step 2 | The bicarbonate formed as the product in the previous step dissociates from the active site, to be replaced by water, before this step can occur. | - | ||||
*All the coordination properties are derived from the representative PDBs.
If no PDB is available, when possible, the coordination properties are derived from the MACiE reaction mechanism.
| Metal/s Function/s in step 2 | |||
| ZN 262 _ | |||
| Function | Evidence | Notes | |
| Increases acidity | appropriatelyPositioned | Zinc increases the acidity of water, promoting the loss of a proton and, thus activtaing the enzyme for the next round of catalysis. | |