 |
PDBsum entry 9gtk
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Signaling protein
|
PDB id
|
|
|
|
9gtk
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Signaling protein
|
|
|
Title:
|
|
Kras in complex with darpin 784_f5
|
|
Structure:
|
|
Isoform 2b of gtpase kras. Chain: a, c, d. Synonym: k-ras 2,ki-ras,c-k-ras,c-ki-ras. Engineered: yes. Darpin 784_f5. Chain: b, h, i. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: kras, kras2, rask2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Organism_taxid: 32630. Expression_system_taxid: 562
|
|
Resolution:
|
|
|
2.00Å
|
R-factor:
|
0.172
|
R-free:
|
0.201
|
|
|
Authors:
|
|
J.N.Kapp,W.Verdurmen,J.V.Schaefer,K.Kopra,G.Nagy-Davidescu,E.Richard, M.J.Nokin,P.Ernst,R.Tamaskovic,M.Schwill,R.Degen,C.Scholl, D.Santamaria,A.Plueckthun
|
|
Key ref:
|
|
J.N.Kapp
et al.
(2025).
A nucleotide-Independent, Pan-Ras-Targeted darpin eli anti-Tumor activity in a multimodal manner..
Mol oncol,
19,
3266.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
18-Sep-24
|
Release date:
|
25-Jun-25
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
Chains A, C, D:
E.C.3.6.5.2
- small monomeric GTPase.
|
|
|
|
|
|
|
Reaction:
|
|
GTP + H2O = GDP + phosphate + H+
|
|
|
|
|
|
GTP
|
+
|
H2O
|
=
|
GDP
Bound ligand (Het Group name = )
matches with 81.82% similarity
|
+
|
phosphate
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
Links
