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PDBsum entry 9fxh
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PDB id:
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Transferase
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Title:
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Crystal structure of cobalt(ii)-substituted double mutant y115e y117e human glutaminyl cyclase
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Structure:
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Glutaminyl-peptide cyclotransferase. Chain: a, b, c. Synonym: glutaminyl cyclase,qc,sqc,glutaminyl-tRNA cyclotransferase, glutamyl cyclase,ec. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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2.30Å
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R-factor:
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0.207
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R-free:
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0.257
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Authors:
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G.Tassone,C.Pozzi,S.Mangani
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Key ref:
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G.Tassone
et al.
(2024).
Metal ion binding to human glutaminyl cyclase: a stru perspective..
Int j mol sci,
25,
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PubMed id:
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Date:
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01-Jul-24
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Release date:
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04-Sep-24
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PROCHECK
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Headers
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References
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Q16769
(QPCT_HUMAN) -
Glutaminyl-peptide cyclotransferase from Homo sapiens
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Seq:
Struc:
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361 a.a.
323 a.a.*
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Key: |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.2.3.2.5
- glutaminyl-peptide cyclotransferase.
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Reaction:
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N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+
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L-glutaminyl-peptide
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=
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5-oxoprolyl-peptide
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+
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NH(3)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
