_EC 2.3.2.5 glutaminyl-peptide cyclotransferase.

67 PDB entries

EC 2.-.-.- Transferases. [47,929 PDB entries] EC 2.3.-.- Acyltransferases. [6,172 PDB entries] EC 2.3.2.- Aminoacyltransferases. [2,603 PDB entries] EC 2.3.2.5 glutaminyl-peptide cyclotransferase. [67 PDB entries]

2afm

Reaction:		N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).
		L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3) Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):		glutaminyl cyclase. glutaminyl-tRNA cyclotransferase.
Comments:		Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 67 PDB entries in enzyme class E.C.2.3.2.5

PDB code		Protein
2afm		Crystal structure of human glutaminyl cyclase at ph 6.5 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2afo		Crystal structure of human glutaminyl cyclase at ph 8.0 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B (321 residues) CATH domain: 3.40.630.10
2afs		Crystal structure of the genetic mutant r54w of human glutaminyl cyclase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2afu		Crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B (321 residues) CATH domain: 3.40.630.10
2afw		Crystal structure of human glutaminyl cyclase in complex with n- acetylhistamine Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2afx		Crystal structure of human glutaminyl cyclase in complex with 1- benzylimidazole Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2afz		Crystal structure of human glutaminyl cyclase in complex with 1- vinylimidazole Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2faw		Crystal structure of papaya glutaminyl cyclase Source: Carica papaya. Papaya. Organism_taxid: 3649. Other_details: latex Chains: A, B (250 residues)
2iwa		Unbound glutaminyl cyclotransferase from carica papaya. Source: Carica papaya. Papaya. Organism_taxid: 3649. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Chain: A (254 residues)
2zed		Crystal structure of the human glutaminyl cyclase mutant s160a at 1.7 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zee		Crystal structure of the human glutaminyl cyclase mutant s160g at 1.99 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zef		Crystal structure of the human glutaminyl cyclase mutant e201d at 1.67 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zeg		Crystal structure of the human glutaminyl cyclase mutant e201l at 2.08 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zeh		Crystal structure of the human glutaminyl cyclase mutant e201q at 1.8 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zel		Crystal structure of the human glutaminyl cyclase mutant d248a at 1.97 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zem		Crystal structure of the human glutaminyl cyclase mutant d248q at 2.18 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zen		Crystal structure of the human glutaminyl cyclase mutant d305a at 1.78 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zeo		Crystal structure of the human glutaminyl cyclase mutant d305e at 1.66 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
2zep		Crystal structure of the human glutaminyl cyclase mutant h319l at 2.1 angstrom resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: bone marrow. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (323 residues) CATH domain: 3.40.630.10
3mbr		Crystal structure of the glutaminyl cyclase from xanthomonas campestris Source: Xanthomonas campestris. Organism_taxid: 340. Strain: pv. Campestris. Gene: xcc2216. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: X (236 residues)
3nok		Crystal structure of myxococcus xanthus glutaminyl cyclase Source: Myxococcus xanthus. Organism_taxid: 34. Strain: dsm 16526. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (234 residues)
3nol		Crystal structure of zymomonas mobilis glutaminyl cyclase (trigonal form) Source: Zymomonas mobilis. Organism_taxid: 555217. Strain: subsp. Mobilis atcc 10988, dsmz 424. Gene: zmobdraft_1643. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (234 residues)
3nom		Crystal structure of zymomonas mobilis glutaminyl cyclase (monoclinic form) Source: Zymomonas mobilis. Organism_taxid: 555217. Strain: subsp. Mobilis atcc 10988, dsmz 424. Gene: zmobdraft_1643. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (234 residues)
3pb4		Crystal structure of the catalytic domain of human golgi-resident glutaminyl cyclase at ph 6.0 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpctl. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: X (311 residues) CATH domain: 3.40.630.10
3pb6		Crystal structure of the catalytic domain of human golgi-resident glutaminyl cyclase at ph 6.5 Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: X (313 residues) CATH domain: 3.40.630.10
3pb7		Crystal structure of the catalytic domain of human golgi-resident glutaminyl cyclase in complex with pbd150 Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: X (309 residues) CATH domain: 3.40.630.10
3pb8		Crystal structure of the catalytic domain of human golgi-resident glutaminyl cyclase in complex with n-acetylhistamine Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpctl. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: X (313 residues) CATH domain: 3.40.630.10
3pb9		Crystal structure of the catalytic domain of human golgi-resident glutaminyl cyclase in complex with 1-benzylimidazole Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpctl. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: X (309 residues) CATH domain: 3.40.630.10
3pbb		Crystal structure of human secretory glutaminyl cyclase in complex with pbd150 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (323 residues) CATH domain: 3.40.630.10
3pbe		Crystal structure of the mutant w207f of human secretory glutaminyl cyclase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (323 residues) CATH domain: 3.40.630.10
3si0		Structure of glycosylated human glutaminyl cyclase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (314 residues) CATH domain: 3.40.630.10
3si1		Structure of glycosylated murine glutaminyl cyclase Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: qpct. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (323 residues) CATH domain: 3.40.630.10
3si2		Structure of glycosylated murine glutaminyl cyclase in presence of the inhibitor pq50 (pdbd150) Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: qpct. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (322 residues) CATH domain: 3.40.630.10
4f9u		Structure of glycosylated glutaminyl cyclase from drosophila melanogaster Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: qc, cg10487, cg32412, dmel_cg32412. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Chains: A, B (298 residues) CATH domain: 3.40.630.10
4f9v		Structure of c113a/c136a mutant variant of glycosylated glutaminyl cyclase from drosophila melanogaster Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: qc, cg10487, cg32412, dmel_cg32412. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Chains: A, B (307 residues) CATH domain: 3.40.630.10
4fai		Crystal structure of mitochondrial isoform of glutaminyl cyclase from drosophila melanogaster Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: isoqc, cg5976, dmel_cg5976. Expressed in: escherichia coli. Expression_system_taxid: 1007065. Chains: A, B (302 residues) CATH domain: 3.40.630.10
4fbe		Crystal structure of the c136a/c164a variant of mitochondrial isoform of glutaminyl cyclase from drosophila melanogaster Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: isoqc, cg5976, dmel_cg5976. Expressed in: escherichia coli. Expression_system_taxid: 1007065. Chains: A, B (303 residues) CATH domain: 3.40.630.10
4fwu		Crystal structure of glutaminyl cyclase from drosophila melanogaster in space group i4 Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: qc, cg10487, cg32412, dmel_cg32412. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Chain: A (299 residues) CATH domain: 3.40.630.10
4mhn		Crystal structure of a glutaminyl cyclase from ixodes scapularis Source: Ixodes scapularis. Blacklegged tick,deer tick,shoulder tick. Organism_taxid: 6945. Gene: iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (326 residues) CATH domain: 3.40.630.10
4mhp		Crystal structure of apo-form of glutaminyl cyclase from ixodes scapularis Source: Ixodes scapularis. Blacklegged tick,deer tick,shoulder tick. Organism_taxid: 6945. Gene: iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (326 residues) CATH domain: 3.40.630.10
4mhy		Crystal structure of a glutaminyl cyclase from ixodes scapularis in complex with pbd150 Source: Ixodes scapularis. Blacklegged tick,deer tick,shoulder tick. Organism_taxid: 6945. Gene: iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (324 residues) CATH domain: 3.40.630.10
4mhz		Crystal structure of apo-form glutaminyl cyclase from ixodes scapularis in complex with pbd150 Source: Ixodes scapularis. Blacklegged tick,deer tick,shoulder tick. Organism_taxid: 6945. Gene: iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (325 residues) CATH domain: 3.40.630.10
4yu9		Crystal structure of double mutant y115e y117e human glutaminyl cyclase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (326 residues) CATH domain: 3.40.630.10
4ywy		Crystal structure of double mutant y115e y117e human glutaminyl cyclase in complex with inhibitor pbd-150 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (326 residues) CATH domain: 3.40.630.10
6gbx		Crystal structure of human glutaminyl cyclase variant y115e-y117e in complex with sen177 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B, C (328 residues)
6yi1		Crystal structure of human glutaminyl cyclase in complex with glu(gamma-hydrazide)-phe-ala Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630 Chains: A, B (329 residues)
6yjy		Crystal structure of human glutaminyl cyclase in complex with neurotensin 1-5 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chains: A, B (329 residues)
7cm0		Crystal structure of a glutaminyl cyclase in complex with nhv-1009 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (321 residues)
7coz		Crystal structure of double mutant y115e y117e human secretory glutaminyl cyclase in complex with lsb-41 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768 Chains: A, B, C (326 residues)
7cp0		Crystal structure of double mutant y115e y117e human secretory glutaminyl cyclase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768 Chains: A, B, C (327 residues)
7d17		Crystal structure of macrostomum lignano glutaminyl cyclase Source: Macrostomum lignano. Organism_taxid: 282301. Gene: box15_mlig028993g1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (321 residues)
7d1h		Crystal structure of ixodes scapularis glutaminyl cyclase with d238a mutation Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (326 residues)
7d1n		Crystal structure of ixodes scapularis glutaminyl cyclase with three cu ions bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (325 residues)
7d1p		Crystal structure of ixodes scapularis glutaminyl cyclase with three cd ions bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (326 residues)
7d1y		Crystal structure of ixodes scapularis glutaminyl cyclase with two co ions bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (325 residues)
7d21		Crystal structure of ixodes scapularis glutaminyl cyclase with two zn ions bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (328 residues)
7d23		Crystal structure of ixodes scapularis glutaminyl cyclase with one k ion bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (326 residues)
7d2b		Crystal structure of ixodes scapularis glutaminyl cyclase with a ni ion bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (326 residues)
7d2d		Crystal structure of ixodes scapularis glutaminyl cyclase with a mn ion bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (326 residues)
7d2i		Crystal structure of ixodes scapularis glutaminyl cyclase with a fe ion bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (325 residues)
7d2j		Crystal structure of ixodes scapularis glutaminyl cyclase with a cd ion bound to the active site Source: Ixodes scapularis. Black-legged tick. Organism_taxid: 6945. Gene: 8042451, iscw_iscw023264. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (326 residues)
7d8e		Crystal structure of double mutant y115e y117e human secretory glutaminyl cyclase in complex with lsb-09 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768 Chains: A, B, C (318 residues)
8hy3		Crystal structure of human secretory glutaminyl cyclase in complex with 1-benzyl-5-methyl-1h-imidazole Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chain: A (323 residues)
9fxg		Crystal structure of double mutant y115e y117e human glutaminyl cyclase in apo-state Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (320 residues)
9fxh		Crystal structure of cobalt(ii)-substituted double mutant y115e y117e human glutaminyl cyclase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (323 residues)
9fxi		Crystal structure of cobalt(ii)-substituted double mutant y115e y117e human glutaminyl cyclase in complex with sen177 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (326 residues)
9fxj		Crystal structure of cobalt(ii)-substituted double mutant y115e y117e human glutaminyl cyclase in complex with pbd-150 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qpct. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (326 residues)