spacer
spacer

PDBsum entry 9dch
Go to PDB code: 
protein dna_rna metals Protein-protein interface(s) links
Gene regulation PDB id
9dch

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
460 a.a.
423 a.a.
405 a.a.
109 a.a.
31 a.a.
365 a.a.
DNA/RNA
Metals
_ZN ×14
PDB id:
9dch
Name: Gene regulation
Title: Single-stranded RNA-mediated prc2 dimer
Structure: Terramut RNA. Chain: g. Engineered: yes. Isoform 2 of histone-lysine n-methyltransferase ezh2. Chain: a, h. Synonym: enx-1,enhancer of zeste homolog 2,lysine n-methyltransferase 6. Engineered: yes. Polycomb protein suz12.
Source: Synthetic: yes. Homo sapiens. Organism_taxid: 9606. Human. Gene: ezh2, kmt6. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: suz12, chet9, jjaz1, kiaa0160. Gene: rbbp4, rbap48.
Authors: J.S.Song,V.K.Kasinath
Key ref: J.Song et al. Diverse RNA structures induce prc2 dimerization and i histone methyltransferase activity.. Biorxiv, . PubMed id: 39257770
Date:
26-Aug-24     Release date:   12-Mar-25    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q15910  (EZH2_HUMAN) -  Histone-lysine N-methyltransferase EZH2 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		746 a.a.
460 a.a.*
Protein chains
Pfam   ArchSchema ?
Q15022  (SUZ12_HUMAN) -  Polycomb protein SUZ12 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		739 a.a.
423 a.a.
Protein chains
Pfam   ArchSchema ?
Q09028  (RBBP4_HUMAN) -  Histone-binding protein RBBP4 from Homo sapiens
Seq:
Struc: 		425 a.a.
405 a.a.
Protein chains
Q6ZN18  (AEBP2_HUMAN) -  Zinc finger protein AEBP2 from Homo sapiens
Seq:
Struc: 		517 a.a.
109 a.a.
Protein chains
Pfam   ArchSchema ?
Q92833  (JARD2_HUMAN) -  Protein Jumonji from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1246 a.a.
31 a.a.
Protein chains
Pfam   ArchSchema ?
O75530  (EED_HUMAN) -  Polycomb protein EED from Homo sapiens
Seq:
Struc: 		441 a.a.
365 a.a.
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 6 residue positions (black crosses)

DNA/RNA chain
  U-G-A-G-U-G-U-G-A-G 10 bases

 Enzyme reactions 
   Enzyme class: Chains A, H: E.C.2.1.1.356  - [histone H3]-lysine(27) N-trimethyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = N6,N6,N6- trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H+
L-lysyl(27)-[histone H3]
 + 3 × S-adenosyl-L-methionine
 = N(6),N(6),N(6)- trimethyl-L-lysyl(27)-[histone H3]
 + 3 × S-adenosyl-L-homocysteine
 + 3 × H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

spacer
spacer