PDBsum entry 8xjs

Membrane protein

PDB id: 8xjs

Contents

Protein chains

517 a.a.

781 a.a.

46 a.a.

32 a.a.

Ligands

LEU-VAL-ASP-ALA-LEU-GLN-PHE-VAL-CYS

PDB id:

8xjs

Name:

Membrane protein

Title:

Cryo-em structure of human insulin receptor bound to 3 igf-i

Structure:

Insulin-like growth factor i. Chain: d, c, e. Engineered: yes. Isoform short of insulin receptor. Chain: b, a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606

Authors:

Z.Xi

Key ref:

Z.Xi Cryo-Em structure of human insulin receptor bound to. To be published, .

Date:

22-Dec-23 Release date: 25-Dec-24

Protein chain

P06213  (INSR_HUMAN) -  Insulin receptor from Homo sapiens

Seq: 1382 a.a.

Struc: 517 a.a.

Protein chain

P06213  (INSR_HUMAN) -  Insulin receptor from Homo sapiens

Seq: 1382 a.a.

Struc: 781 a.a.

Protein chain

P05019  (IGF1_HUMAN) -  Insulin-like growth factor 1 from Homo sapiens

Seq: 195 a.a.

Struc: 46 a.a.

Protein chain

P05019  (IGF1_HUMAN) -  Insulin-like growth factor 1 from Homo sapiens

Seq: 195 a.a.

Struc: 32 a.a.

Enzyme reactions

• Enzyme class: Chains B, A: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site