PDBsum entry 8v8c

Membrane protein

PDB id: 8v8c

Contents

Protein chains

373 a.a.

Ligands

NAG-NAG ×5

NAG ×10

EPJ ×5

I34 ×5

Metals

_CA ×3

PDB id:

8v8c

Name:

Membrane protein

Title:

Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and pnu-120596 asymmetric state 1

Structure:

Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562. Chain: a, b, c, d, e. Synonym: cytochrome b-562. Engineered: yes. Other_details: 351-353 (linker) 354-460 (soluble cytochrome b562 fusion) 551-558 (strep tag ii) 559-571 (linker) 572-579 (strep tag ii) 580-582 (linker) 583-599 (t2a self cleaving peptide post cleavage),351-353 (linker) 354-460 (soluble cytochrome b562 fusion)

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: chrna7, nachra7, cybc. Expressed in: homo sapiens. Expression_system_taxid: 9606

Authors:

S.M.Burke,C.M.Noviello,R.E.Hibbs

Key ref:

S.M.Burke et al. Structural mechanisms of a7 nicotinic receptor allost modulation and activation. Cell(cambridge,Mass ), . PubMed id: 38382524

Date:

05-Dec-23 Release date: 21-Feb-24

Protein chains

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 373 a.a.*

Protein chains

P36544  (ACHA7_HUMAN) -  Neuronal acetylcholine receptor subunit alpha-7 from Homo sapiens

Seq: 502 a.a.

Struc: 373 a.a.

* PDB and UniProt seqs differ at 24 residue positions (black crosses)