PDBsum entry 8siv

Transferase

PDB id: 8siv

Contents

Protein chain

262 a.a.

Ligands

ZXH

Waters ×149

PDB id:

8siv

Name:

Transferase

Title:

Structure of compound 2 bound to the chk1 10-point mutant

Structure:

Serine/threonine-protein kinase chk1. Chain: a. Synonym: chk1 checkpoint homolog,cell cycle checkpoint kinase, checkpoint kinase-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: chek1, chk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.76Å R-factor: 0.210 R-free: 0.251

Authors:

R.L.Palte

Key ref:

S.D.Kattar et al. Discovery of mk-1468: a potent, Kinome-Selective, Brain-Penetrant amidoisoquinoline lrrk2 inhibitor for potential treatment of parkinson'S disease.. J med chem, . PubMed id: 37861679

Date:

17-Apr-23 Release date: 01-Nov-23

Protein chain

O14757  (CHK1_HUMAN) -  Serine/threonine-protein kinase Chk1 from Homo sapiens

Seq: 476 a.a.

Struc: 262 a.a.*

* PDB and UniProt seqs differ at 10 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site