PDBsum entry 8sio

Transferase/inhibitor

PDB id: 8sio

Contents

Protein chains

301 a.a.

Ligands

GXF ×2

Waters ×124

PDB id:

8sio

Name:

Transferase/inhibitor

Title:

Crystal structure of prmt3 with yd1-66

Structure:

Protein arginine n-methyltransferase 3. Chain: a, b. Synonym: heterogeneous nuclear ribonucleoprotein methyltransferase- like protein 3. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: prmt3, hrmt1l3. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.20Å R-factor: 0.194 R-free: 0.236

Authors:

X.Song,A.Dong,C.H.Arrowsmith,A.M.Edwards,Y.Deng,R.Huang,J.Min

Key ref:

X.Song et al. Crystal structure of prmt3 with yd1-66. To be published, .

Date:

16-Apr-23 Release date: 17-Apr-24

Protein chains

O60678  (ANM3_HUMAN) -  Protein arginine N-methyltransferase 3 from Homo sapiens

Seq: 531 a.a.

Struc: 301 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.1.319 - type I protein arginine methyltransferase.
• Reaction: L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)- dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺

L-arginyl-[protein] + 2 × S-adenosyl-L-methionine = N(omega),N(omega)- dimethyl-L-arginyl-[protein] + 2 × S-adenosyl-L-homocysteine + 2 × H(+) (Bound ligand (Het Group name = GXF) matches with 54.76% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site