|
|
||
|
|
|
|
|
UniProt functional annotation for O60678 | ||
|
|
|
|
|
|
||
| UniProt code: O60678. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. |
|
||
| Activity regulation: | |
Inhibited by N-ethylmaleimide and high concentrations of zinc chloride. {ECO:0000250}. |
| Subunit: | |
Monomer or homodimer (By similarity). Interacts with EPB41L3; this inhibits methylation of target proteins. Interacts with the 40S ribosomal protein RPS2. {ECO:0000250, ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:21059412, ECO:0000269|Ref.16}. |
| Subcellular location: | |
Cytoplasm. |
| Domain: | |
The zinc-finger is responsible for substrate specificity. {ECO:0000250}. |
| Similarity: | |
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU01015}. |
Annotations taken from UniProtKB at the EBI.