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PDBsum entry 8s4f
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PDB id:
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Lyase
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Title:
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Human carbonic anhydrase i covalently bound to av21-08
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Structure:
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Carbonic anhydrase 1. Chain: a, b. Synonym: carbonate dehydratase i,carbonic anhydrase b,cab,carbonic anhydrase i,ca-i,cyanamide hydratase ca1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ca1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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1.39Å
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R-factor:
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0.205
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R-free:
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0.234
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Authors:
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E.N.Manakova,S.Grazulis,V.Paketuryte-Latve,A.Vaskevicius,A.Smirnov
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Key ref:
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A.Vaskevicius
et al.
Targeted anticancer pre-Vinylsulfone covalent inhibit carbonic anhydrase IX.
Elife,
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PubMed id:
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Date:
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21-Feb-24
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Release date:
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18-Dec-24
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PROCHECK
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Headers
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References
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P00915
(CAH1_HUMAN) -
Carbonic anhydrase 1 from Homo sapiens
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Seq:
Struc:
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261 a.a.
256 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class 2:
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E.C.4.2.1.1
- carbonic anhydrase.
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Reaction:
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hydrogencarbonate + H+ = CO2 + H2O
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hydrogencarbonate
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+
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H(+)
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=
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CO2
Bound ligand (Het Group name = )
matches with 60.00% similarity
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+
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H2O
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Cofactor:
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Zn(2+)
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Enzyme class 3:
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E.C.4.2.1.69
- cyanamide hydratase.
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Reaction:
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urea = cyanamide + H2O
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urea
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=
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cyanamide
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+
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H2O
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
