PDBsum entry 8qcc

Transferase

PDB id: 8qcc

Contents

Protein chains

281 a.a.

Ligands

ADP ×2

UKO ×2

Metals

_MG ×5

Waters ×186

PDB id:

8qcc

Name:

Transferase

Title:

E.Coli ispe in complex with a ligand (1)

Structure:

4-diphosphocytidyl-2-c-methyl-d-erythritol kinase. Chain: a, b. Engineered: yes

Source:

Escherichia coli. Organism_taxid: 562. Gene: ispe. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å R-factor: 0.196 R-free: 0.235

Authors:

R.Hamid

Key ref:

R.Hamid E.Coli ispe in complex with a ligand (1). To be published, . PubMed id: 39510075

Date:

25-Aug-23 Release date: 11-Sep-24

Protein chains

P62615  (ISPE_ECOLI) -  4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from Escherichia coli (strain K12)

Seq: 283 a.a.

Struc: 281 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.1.148 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
• Reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H⁺

4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP (Bound ligand (Het Group name = ADP) corresponds exactly) + H(+)

• Cofactor: Mn(2+) or Mg(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site