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PDBsum entry 8osj
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protein dna_rna Protein-protein interface(s) links
Gene regulation PDB id
8osj

 

 

 

 

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Contents
Protein chains
89 a.a.
79 a.a.
100 a.a.
90 a.a.
63 a.a.
54 a.a.
DNA/RNA
PDB id:
8osj
Name: Gene regulation
Title: Cryo-em structure of clock-bmal1 bound to a nucleosomal e-box at position shl-6.2 (DNA conformation 1)
Structure: Histone h3.1. Chain: a, e. Synonym: histone h3/a,histone h3/b,histone h3/c,histone h3/d,histone h3/f,histone h3/h,histone h3/i,histone h3/j,histone h3/k,histone h3/l. Engineered: yes. Histone h4. Chain: b, f. Engineered: yes.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hist1h3a, h3fa, hist1h3b, h3fl, hist1h3c, h3fc, hist1h3d, h3fb, hist1h3e, h3fd, hist1h3f, h3fi, hist1h3g, h3fh, hist1h3h, h3fk, hist1h3i, h3ff, hist1h3j, h3fj. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: hist1h4a, h4/a, h4fa, hist1h4b, h4/i, h4fi, hist1h4c, h4/g,
Authors: A.K.Michael,L.Stoos,G.Kempf,S.Cavadini,N.H.Thoma
Key ref: X.Xyz To be published.. To be published, . PubMed id: 37407816
Date:
19-Apr-23     Release date:   24-May-23    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P68431  (H31_HUMAN) -  Histone H3.1 from Homo sapiens
Seq:
Struc: 		136 a.a.
89 a.a.
Protein chains
Pfam   ArchSchema ?
P62805  (H4_HUMAN) -  Histone H4 from Homo sapiens
Seq:
Struc: 		103 a.a.
79 a.a.
Protein chains
Pfam   ArchSchema ?
P04908  (H2A1B_HUMAN) -  Histone H2A type 1-B/E from Homo sapiens
Seq:
Struc: 		130 a.a.
100 a.a.
Protein chains
Pfam   ArchSchema ?
P06899  (H2B1J_HUMAN) -  Histone H2B type 1-J from Homo sapiens
Seq:
Struc: 		126 a.a.
90 a.a.
Protein chain
Pfam   ArchSchema ?
O08785  (CLOCK_MOUSE) -  Circadian locomoter output cycles protein kaput from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		855 a.a.
63 a.a.
Protein chain
Pfam   ArchSchema ?
Q9WTL8  (BMAL1_MOUSE) -  Basic helix-loop-helix ARNT-like protein 1 from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		632 a.a.
54 a.a.
Key:    PfamA domain  Secondary structure

DNA/RNA chains
  G-G-G-T-C-A-C-G-T-G-C-T-G-C-A-G-G-C-C-G-C-T-C-A-A-T-T-G-G-T-C-G-T-A-G-A-C-A-G- 128 bases
  T-C-T-G-A-C-A-C-G-T-G-C-C-T-G-G-A-G-A-C-T-A-G-G-G-A-G-T-A-A-T-C-C-C-C-T-T-G-G- 128 bases

 Enzyme reactions 
   Enzyme class: Chain M: E.C.2.3.1.48  - histone acetyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-lysyl-[protein] + acetyl-CoA = N6-acetyl-L-lysyl-[protein] + CoA + H+
L-lysyl-[protein]
 + acetyl-CoA
 = N(6)-acetyl-L-lysyl-[protein]
 + CoA
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

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