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PDBsum entry 8e8s
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Virus/immune system
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PDB id
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8e8s
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Contents |
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273 a.a.
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262 a.a.
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235 a.a.
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53 a.a.
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126 a.a.
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110 a.a.
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PDB id:
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| Name: |
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Virus/immune system
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Title:
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9h2 fab-poliovirus 2 complex
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Structure:
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Capsid protein vp1. Chain: 1. Capsid protein vp2. Chain: 2. Capsid protein vp3. Chain: 3. Capsid protein vp4. Chain: 4. 9h2 fab heavy chain.
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Source:
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Poliovirus 2. Organism_taxid: 12083. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_taxid: 9606
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Authors:
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A.J.Charnesky
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Key ref:
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A.J.Charnesky
et al.
High resolution cryo em structures show a human monoc antibody binds into the canyon to neutralize all thre serotypes of poliovirus.
To be published,
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PubMed id:
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Date:
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25-Aug-22
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Release date:
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21-Jun-23
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PROCHECK
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Headers
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References
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P06210
(POLG_POL2L) -
Genome polyprotein from Poliovirus type 2 (strain Lansing)
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Seq:
Struc:
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2207 a.a.
273 a.a.
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P06210
(POLG_POL2L) -
Genome polyprotein from Poliovirus type 2 (strain Lansing)
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Seq:
Struc:
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2207 a.a.
262 a.a.*
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P06210
(POLG_POL2L) -
Genome polyprotein from Poliovirus type 2 (strain Lansing)
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Seq:
Struc:
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2207 a.a.
235 a.a.
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P06210
(POLG_POL2L) -
Genome polyprotein from Poliovirus type 2 (strain Lansing)
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Seq:
Struc:
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2207 a.a.
53 a.a.
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Enzyme class 2:
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Chains 1, 2, 3, 4:
E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Enzyme class 3:
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Chains 1, 2, 3, 4:
E.C.3.4.22.28
- picornain 3C.
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Reaction:
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Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 4:
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Chains 1, 2, 3, 4:
E.C.3.4.22.29
- picornain 2A.
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Reaction:
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Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 5:
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Chains 1, 2, 3, 4:
E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
