PDBsum entry 8bsr

Hydrolase

PDB id: 8bsr

Contents

Protein chain

351 a.a.

Ligands

SO4 ×6

NAG

DMS

RCU

EDO ×3

Waters ×116

PDB id:

8bsr

Name:

Hydrolase

Title:

Notum inhibitor aruk3006562

Structure:

Palmitoleoyl-protein carboxylesterase notum. Chain: a. Synonym: hnotum. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: notum, ok/sw-cl.30. Expressed in: homo sapiens. Expression_system_taxid: 9606

Resolution:

1.45Å R-factor: 0.200 R-free: 0.206

Authors:

Y.Zhao,E.Y.Jones,P.Fish

Key ref:

Y.Zhao et al. Notum inhibitor. To be published, . PubMed id: 36934521

Date:

26-Nov-22 Release date: 14-Dec-22

Protein chain

Q6P988  (NOTUM_HUMAN) -  Palmitoleoyl-protein carboxylesterase NOTUM from Homo sapiens

Seq: 496 a.a.

Struc: 351 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
• Reaction: [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = [Wnt protein]-L-serine + (9Z)-hexadecenoate + H⁺