UniProt functional annotation for Q6P988



	UniProt functional annotation for Q6P988

UniProt code: Q6P988.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). {ECO:0000269|PubMed:25731175}.

Catalytic activity: Reaction=[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)- hexadecenoate + [Wnt protein]-L-serine + H(+); Xref=Rhea:RHEA:45340, Rhea:RHEA-COMP:11170, Rhea:RHEA-COMP:11171, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:32372, ChEBI:CHEBI:85189; EC=3.1.1.98; Evidence={ECO:0000269|PubMed:25731175};

Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.

Tissue specificity: Rarely expressed in adult normal tissues. {ECO:0000269|PubMed:18429952}.

Induction: Up-regulated in hepatocellular carcinoma (HCC) with high intracellular beta-catenin. {ECO:0000269|PubMed:18429952}.

Similarity: Belongs to the pectinacetylesterase family. Notum subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAH36872.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH60882.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB93501.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). {ECO:0000269\|PubMed:25731175}.


Catalytic activity:		Reaction=[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)- hexadecenoate + [Wnt protein]-L-serine + H(+); Xref=Rhea:RHEA:45340, Rhea:RHEA-COMP:11170, Rhea:RHEA-COMP:11171, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:32372, ChEBI:CHEBI:85189; EC=3.1.1.98; Evidence={ECO:0000269\|PubMed:25731175};
Subcellular location:		Secreted {ECO:0000250\|UniProtKB:Q9VUX3}.
Tissue specificity:		Rarely expressed in adult normal tissues. {ECO:0000269\|PubMed:18429952}.
Induction:		Up-regulated in hepatocellular carcinoma (HCC) with high intracellular beta-catenin. {ECO:0000269\|PubMed:18429952}.
Similarity:		Belongs to the pectinacetylesterase family. Notum subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAH36872.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH60882.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB93501.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};