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PDBsum entry 7zdd
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Transcription
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PDB id
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7zdd
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PDB id:
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| Name: |
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Transcription
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Title:
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Crystal structure of trim33 phd-bromodomain isoform b in complex with h3k10ac histone peptide.
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Structure:
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E3 ubiquitin-protein ligase trim33. Chain: a. Fragment: unp residues 882-1073. Synonym: ectodermin homolog,ret-fused gene 7 protein,protein rfg7, transcription intermediary factor 1-gamma,tif1-gamma,tripartite motif-containing protein 33. Engineered: yes. Histone h3.X. Chain: d.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: trim33, kiaa1113, rfg7, tif1g. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: peptide contains an extra lysine on thE C-terminus when compared with the wild-type [artkqtark(ac)]
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Resolution:
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1.63Å
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R-factor:
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0.210
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R-free:
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0.250
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Authors:
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S.Caria,S.Duclos,S.Crespillo,J.Errey,J.J.Barker
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Key ref:
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A.Sekirnik
et al.
Identification of histone peptide binding specificity small molecule ligands for the bromodomains of trim33 and trim33 beta.
To be published,
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PubMed id:
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Date:
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29-Mar-22
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Release date:
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29-Jun-22
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PROCHECK
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Headers
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References
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Q9UPN9
(TRI33_HUMAN) -
E3 ubiquitin-protein ligase TRIM33 from Homo sapiens
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Seq:
Struc:
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1127 a.a.
176 a.a.
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Enzyme class:
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E.C.2.3.2.27
- RING-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Links
