PDBsum entry 7wcw

Transferase/transferase inhibitor

PDB id: 7wcw

Contents

Protein chain

300 a.a.

Ligands

90F

SO4 ×3

Waters ×123

PDB id:

7wcw

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of fgfr4(v550l) kinase domain with 7v

Structure:

Fibroblast growth factor receptor 4. Chain: a. Synonym: fgfr-4. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.32Å R-factor: 0.179 R-free: 0.221

Authors:

X.J.Chen,Q.M.Lin,S.Y.Dai,Y.H.Chen

Key ref:

M.Shao et al. Design, Synthesis, And biological evaluation of aminoindazole derivatives as highly selective covalen inhibitors of wild-Type and gatekeeper mutant fgfr4.. J med chem, . PubMed id: 35271262

Date:

20-Dec-21 Release date: 30-Mar-22

Protein chain

P22455  (FGFR4_HUMAN) -  Fibroblast growth factor receptor 4 from Homo sapiens

Seq: 802 a.a.

Struc: 300 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site