PDBsum entry 7uhh

Hydrolase

PDB id: 7uhh

Contents

Protein chain

264 a.a.

Ligands

MX0

Metals

_ZN ×2

Waters ×49

PDB id:

7uhh

Name:

Hydrolase

Title:

Time-resolved structure of metallo beta-lactamase l1 in a complex with non-hydrolyzed moxalactam (20 ms snapshot)

Structure:

Putative metallo-beta-lactamase l1 (beta-lactamase type ii) (ec 3.5.2.6) (penicillinase). Chain: a. Engineered: yes

Source:

Stenotrophomonas maltophilia k279a. Organism_taxid: 522373. Strain: k279a. Gene: smlt2667. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: gold

Resolution:

2.20Å R-factor: 0.225 R-free: 0.262

Authors:

M.Wilamowski,Y.Kim,D.A.Sherrell,A.Lavens,R.Henning,N.Maltseva, M.Endres,G.Babnigg,V.Srajer,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)

Key ref:

M.Wilamowski et al. Time-Resolved structure of metallo beta-Lactamase l1 complex with non-Hydrolyzed moxalactam (20 ms snapsho. To be published, . PubMed id: 36450742

Date:

27-Mar-22 Release date: 13-Apr-22

Protein chain

B2FTM1  (B2FTM1_STRMK) -  Metallo-beta-lactamase l1 (Beta-lactamase type ii) (Ec 3.5.2.6) (Penicillinase) from Stenotrophomonas maltophilia (strain K279a)

Seq: 290 a.a.

Struc: 264 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)