PDBsum entry 7os2

Splicing

PDB id: 7os2

Contents

Protein chains

1726 a.a.

54 a.a.

266 a.a.

PDB id:

7os2

Name:

Splicing

Title:

Cryo-em structure of brr2 in complex with jab1/mpn and c9orf78

Structure:

U5 small nuclear ribonucleoprotein 200 kda helicase. Chain: b. Engineered: yes. Telomere length and silencing protein 1 homolog. Chain: c. Engineered: yes. Pre-mRNA-processing-splicing factor 8. Chain: j. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: c9orf78. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: prpf8.

Authors:

A.Bergfort,T.Hilal,G.Weber,M.C.Wahl

Key ref:

A.Bergfort et al. Regulation of alternative splicing by c9orf78, A nove interactor. To be published, . PubMed id: 35188580

Date:

07-Jun-21 Release date: 23-Feb-22

Protein chain

O75643  (U520_HUMAN) -  U5 small nuclear ribonucleoprotein 200 kDa helicase from Homo sapiens

Seq: 2136 a.a.

Struc: 1726 a.a.

Protein chain

Q9NZ63  (TLS1_HUMAN) -  Splicing factor C9orf78 from Homo sapiens

Seq: 289 a.a.

Struc: 54 a.a.

Protein chain

Q6P2Q9  (PRP8_HUMAN) -  Pre-mRNA-processing-splicing factor 8 from Homo sapiens

Seq: 2335 a.a.

Struc: 266 a.a.

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.4.13 - Rna helicase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site