Crystal structure of the l452r mutant receptor binding domain of sars- cov-2 spike glycoprotein in complex with covox-75 and covox-253 fabs
Structure:
Spike protein s1. Chain: r, x. Engineered: yes. Covox-253 fab heavy chain. Chain: h, c. Engineered: yes. Covox-253 fab light chain. Chain: l, d. Engineered: yes.
Source:
Severe acute respiratory syndrome coronavirus 2. 2019-ncov, sars-cov-2. Organism_taxid: 2697049. Gene: s, 2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Organism_taxid: 9606.
Resolution:
2.50Å
R-factor:
0.215
R-free:
0.251
Authors:
D.Zhou,J.Ren,D.I.Stuart
Key ref:
C.Liu
et al.
(2021).
Reduced neutralization of sars-Cov-2 b.1.617 by vacci convalescent serum..
Cell,
184,
4220.
PubMed id: 34242578
Date:
04-Jun-21
Release date:
07-Jul-21
PROCHECK
Headers
References
Protein chains
P0DTC2 (SPIKE_SARS2) -
Spike glycoprotein from Severe acute respiratory syndrome coronavirus 2
Seq: Struc:
Seq: Struc:
Seq: Struc:
1273 a.a.
185 a.a.*
Protein chains
No UniProt id for this chain
Struc:
219 a.a.
Protein chains
No UniProt id for this chain
Struc:
214 a.a.
Protein chains
No UniProt id for this chain
Struc:
224 a.a.
Protein chains
No UniProt id for this chain
Struc:
214 a.a.
Key:
PfamA domain
Secondary structure
*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
Links
