PDBsum entry 7k8h

Structural protein

PDB id: 7k8h

Contents

Protein chains

265 a.a.

Ligands

PO4 ×2

9F2 ×2

9F2-PO4 ×2

Waters ×247

PDB id:

7k8h

Name:

Structural protein

Title:

Beta-lactamase mixed with ceftriaxone, 50ms

Structure:

Beta-lactamase. Chain: a, b, c, d. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: blac, ers027646_02769. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.60Å R-factor: 0.225 R-free: 0.275

Authors:

S.Pandey,M.Schmidt

Key ref:

S.Pandey et al. (2021). Observation of substrate diffusion and ligand binding enzyme crystals using high-Repetition-Rate mix-And-In serial crystallography. Iucrj, 8, .

Date:

27-Sep-20 Release date: 22-Sep-21

Protein chains

P9WKD3  (BLAC_MYCTU) -  Beta-lactamase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 307 a.a.

Struc: 265 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)