PDBsum entry 7gpp

Viral protein

PDB id: 7gpp

Contents

Protein chains

182 a.a.

Ligands

U29

DMS

Waters ×312

PDB id:

7gpp

Name:

Viral protein

Title:

Pandda analysis group deposition -- crystal structure of enterovirus d68 3c protease in complex with pob0050

Structure:

Protease 3c. Chain: a, b. Synonym: picornain 3c,p3c. Engineered: yes

Source:

Enterovirus d68. Organism_taxid: 42789. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.57Å R-factor: 0.195 R-free: 0.217

Authors:

R.M.Lithgo,M.Fairhead,L.Koekemoer,J.C.Aschenbrenner,B.H.Balcomb, A.S.Godoy,P.G.Marples,X.Ni,C.W.E.Tomlinson,W.Thompson,C.Wild, D.Fearon,M.A.Walsh,F.Von Delft

Key ref:

R.M.Lithgo et al. Pandda analysis group deposition. To be published, . PubMed id: 38746446

Date:

24-Aug-23 Release date: 29-Nov-23

Protein chains

Q68T42  (POLG_HED68) -  Genome polyprotein from Human enterovirus D68

Seq: 2188 a.a.

Struc: 182 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: E.C.2.7.7.48 - RNA-directed Rna polymerase.
• Reaction: RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
• Enzyme class 3: E.C.3.4.22.28 - picornain 3C.
• Reaction: Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
• Enzyme class 4: E.C.3.4.22.29 - picornain 2A.
• Reaction: Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
• Enzyme class 5: E.C.3.6.1.15 - nucleoside-triphosphate phosphatase.
• Reaction: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site