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PDBsum entry 7fud
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PDB id:
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Transferase
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Title:
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Crystal structure of human cyclic gmp-amp synthase in complex with 5- benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4h- [1,2,4]triazolo[1,5-a]pyrimidin-7-one
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Structure:
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Cyclic gmp-amp synthase. Chain: a, b. Fragment: unp residues 161-522. Synonym: cgamp synthase,cgas,h-cgas,2'3'-cgamp synthase,mab-21 domain-containing protein 1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cgas, c6orf150, mb21d1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.03Å
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R-factor:
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0.197
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R-free:
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0.249
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Authors:
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L.Leibrock,J.Benz,K.Groebke-Zbinden,M.G.Rudolph
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Key ref:
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K.Groebke-Zbinden
et al.
Crystal structure of a human cyclic gmp-Amp synthase.
To be published,
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Date:
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08-Feb-23
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Release date:
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21-Feb-24
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PROCHECK
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Headers
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References
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Q8N884
(CGAS_HUMAN) -
Cyclic GMP-AMP synthase from Homo sapiens
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Seq:
Struc:
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522 a.a.
351 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.7.86
- cyclic GMP-AMP synthase.
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Reaction:
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GTP + ATP = 2',3'-cGAMP + 2 diphosphate
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GTP
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+
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ATP
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=
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2',3'-cGAMP
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+
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2
×
diphosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
