 |
PDBsum entry 7be5
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Crystal structure of map kinase p38 alpha in complex with inhibitor sr276
|
|
Structure:
|
|
Mitogen-activated protein kinase 14. Chain: a. Synonym: mapk 14,crk1,mitogen-activated protein kinase p38 alpha,map kinase p38 alpha. Engineered: yes
|
|
Source:
|
|
Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
Resolution:
|
|
|
1.80Å
|
R-factor:
|
0.187
|
R-free:
|
0.222
|
|
|
Authors:
|
|
A.C.Joerger,M.Schroeder,S.Roehm,S.Knapp,Structural Genomics Consortium (Sgc)
|
|
Date:
|
|
|
22-Dec-20
|
Release date:
|
03-Mar-21
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P47811
(MK14_MOUSE) -
Mitogen-activated protein kinase 14 from Mus musculus
|
|
|
|
Seq:
Struc:
|
|
|
|
360 a.a.
329 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.7.11.24
- mitogen-activated protein kinase.
|
|
|
|
|
|
|
Reaction:
|
|
|
1.
|
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
|
|
2.
|
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
|
|
|
|
|
|
|
L-seryl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-seryl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
L-threonyl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-threonyl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
