EC 2.7.11.24 - mitogen-activated protein kinase.

_EC 2.7.11.24 mitogen-activated protein kinase.

765 PDB entries

EC 2.-.-.- Transferases. [47,727 PDB entries]

EC 2.7.-.- Transferring phosphorus-containing groups. [28,060 PDB entries]

EC 2.7.11.- Protein-serine/threonine kinases. [7,384 PDB entries]

EC 2.7.11.24 mitogen-activated protein kinase. [765 PDB entries]

1a9u

Reaction: (1) L-seryl-[protein] + Atp = O-phospho-L-seryl-[protein] + adp + H(+). (2) L-threonyl-[protein] + Atp = O-phospho-L-threonyl-[protein] + adp + H(+).

L-seryl-[protein]
+
ATP
= O-phospho-L-seryl-[protein]
+
ADP
+ H(+)

L-threonyl-[protein]
+
ATP
= O-phospho-L-threonyl-[protein]
+
ADP
+ H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): c-Jun N-terminal kinase. Erk. extracellular signal-regulated kinase. Jnk. Mapk. Map kinase. Mbp kinase i. Mbp kinase ii. microtubule-associated protein 2 kinase. microtubule-associated protein kinase.

Comments: Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by Ec 2.7.12.2 is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian Mapk pathways can be recruited by a wide variety of stimuli

Links: [IntEnz] [ExPASy] [KEGG]

There are 765 PDB entries in enzyme class E.C.2.7.11.24

PDB code Protein

1a9u

The complex structure of the map kinase p38/sb203580

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21 (de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_cell_line: bl21 (de3).

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

1bl6

The complex structure of the map kinase p38/sb216995

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21 (de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_cell_line: bl21(de3).

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

1bl7

The complex structure of the map kinase p38/sb220025

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21 (de3). Gene: p38. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_cell_line: bl21(de3). Other_details: yes

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

1bmk

The complex structure of the map kinase p38/sb218655

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21 (de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_cell_line: bl21(de3). Other_details: yes

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

1cm8

Phosphorylated map kinase p38-gamma

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (329 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

1di9

The structure of p38 mitogen-activated protein kinase in complex with 4-[3-methylsulfanylanilino]-6,7-dimethoxyquinazoline

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

1gol

Coordinates of rat map kinase erk2 with an arginine mutation at position 52

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Cell_line: bl21. Gene: erk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (357 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1ian

Human p38 map kinase inhibitor complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: b834. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (328 residues)

1jnk

ThE C-jun n-terminal kinase (jnk3s) complexed with mgamp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

1kv1

P38 map kinase in complex with inhibitor 1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

1kv2

Human p38 map kinase in complex with birb 796

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (325 residues) CATH domains: 3.30.200.20 1.10.510.10

1lew

Crystal structure of map kinase p38 complexed to the docking site on its nuclear substrate mef2a

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Homo sapiens. Human.

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

1lez

Crystal structure of map kinase p38 complexed to the docking site on its activator mkk3b

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: p38. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

1m7q

Crystal structure of p38 map kinase in complex with a dihydroquinazolinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

1ouk

The structure of p38 alpha in complex with a pyridinylimidazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

1ouy

The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

1ove

The structure of p38 alpha in complex with a dihydroquinolinone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

1oz1

P38 mitogen-activated kinase in complex with 4-azaindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14 or csbp1 or csbp2 or csbp or mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

1pme

Structure of penta mutant human erk2 map kinase complexed with a specific inhibitor of human p38 map kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

1pmn

Crystal structure of jnk3 in complex with an imidazole-pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mk10_human. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

1pmu

The crystal structure of jnk3 in complex with a phenantroline inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mk10_human. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

1pmv

The structure of jnk3 in complex with a dihydroanthrapyrazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mk10_human. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

1r39

The structure of p38alpha

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp1, csbp2, csbp or mxi2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

1r3c

The structure of p38alpha c162s mutant

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

1tvo

The structure of erk2 in complex with a small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell: dh5alfa.

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

1ukh

Structural basis for the selective inhibition of jnk1 by the scaffolding protein jip1 and sp600125

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs peptide synthesis

Chain: A (321 residues) CATH domains: 3.30.200.20 1.10.510.10

1uki

Structural basis for the selective inhibition of jnk1 by the scaffolding protein jip1 and sp600125

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs peptide synthesis

Chain: A (328 residues) CATH domains: 3.30.200.20 1.10.510.10

1w7h

P38 kinase crystal structure in complex with small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1w82

P38 kinase crystal structure in complex with small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1w83

P38 kinase crystal structure in complex with small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1w84

P38 kinase crystal structure in complex with small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1wbn

Fragment based p38 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1wbo

Fragment based p38 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

1wbs

Identification of novel p38 alpha map kinase inhibitors using fragment-based lead generation.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1wbt

Identification of novel p38 alpha map kinase inhibitors using fragment-based lead generation.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1wbv

Identification of novel p38 alpha map kinase inhibitors using fragment-based lead generation.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1wbw

Identification of novel p38 alpha map kinase inhibitors using fragment-based lead generation.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

1wfc

Structure of apo, unphosphorylated, p38 mitogen activated protein kinase p38 (p38 map kinase) the mammalian homologue of the yeast hog1 protein

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

1wzy

Crystal structure of human erk2 complexed with a pyrazolopyridazine derivative

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

1yqj

Crystal structure of p38 alpha in complex with a selective pyridazine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (356 residues) CATH domains: 3.30.200.20 1.10.510.10

1yw2

Mutated mus musculus p38 kinase (mp38)

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

1ywr

Crystal structure analysis of inactive p38 kinase domain in complex with a monocyclic pyrazolone inhibitor

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

1zyj

Human p38 map kinase in complex with inhibitor 1a

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

1zz2

Two classes of p38alpha map kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

1zzl

Crystal structure of p38 with triazolopyridine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

2b1p

Inhibitor complex of jnk3

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

2b9f

Crystal structure of non-phosphorylated fus3

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fus3, dac2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

2b9h

Crystal structure of fus3 with a docking motif from ste7

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fus3, dac2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the ste7 docking motif was chemically synthesized. The sequence of this peptide naturally exists in saccharomyces

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

2b9i

Crystal structure of fus3 with a docking motif from msg5

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fus3, dac2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the msg5 docking motif was chemically synthesized. The sequence of this peptide naturally exists in saccharomyces

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

2b9j

Crystal structure of fus3 with a docking motif from far1

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fus3, dac2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the far1 docking motif was chemically synthesized. The sequence of this peptide naturally exists in saccharomyces

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

2baj

P38alpha bound to pyrazolourea

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21(de3).

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

2bak

P38alpha map kinase bound to mpaq

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21(de3).

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

2bal

P38alpha map kinase bound to pyrazoloamine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21(de3).

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

2baq

P38alpha bound to ro3201195

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21(de3).

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

2erk

Phosphorylated map kinase erk2

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Cell_line: bl21. Gene: erk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (353 residues) CATH domains: 3.30.200.20 1.10.510.10

2ewa

Dual binding mode of pyridinylimidazole to map kinase p38

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

2exc

Inhibitor complex of jnk3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: X (335 residues) CATH domains: 3.30.200.20 1.10.510.10

2f49

Crystal structure of fus3 in complex with a ste5 peptide

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fus3, dac2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this peptide was chemically synthesized but this sequence naturally occurs in the ste5 protein from s. Cerevisiae

Chains: A, B (335 residues) CATH domains: 3.30.200.20 1.10.510.10

2f9g

Crystal structure of fus3 phosphorylated on tyr182

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fus3, dac2. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: recombinant fus3 was incubated with an activator peptide from ste5 to achieve full phosphorylation on tyr182 by autophsophorylation.

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

2fa2

Crystal structure of fus3 without a peptide from ste5

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fus3, dac2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (333 residues) CATH domains: 3.30.200.20 1.10.510.10

2fsl

Mitogen activated protein kinase p38alpha (d176a+f327s) activating mutant form-a

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: X (332 residues) CATH domains: 3.30.200.20 1.10.510.10

2fsm

Mitogen activated protein kinase p38alpha (d176a+f327s) activating mutant form-b

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: X (326 residues) CATH domains: 3.30.200.20 1.10.510.10

2fso

Mitogen activated protein kinase p38alpha (d176a) activating mutant

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: X (325 residues) CATH domains: 3.30.200.20 1.10.510.10

2fst

Mitogen activated protein kinase p38alpha (d176a+f327l) activating mutant

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: X (324 residues) CATH domains: 3.30.200.20 1.10.510.10

2fys

Crystal structure of erk2 complex with kim peptide derived from mkp3

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized.

Chains: B, A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

2g01

Pyrazoloquinolones as novel, selective jnk1 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the sequence is found naturally in homo sapiens (human).

Chains: A, B (356 residues) CATH domains: 3.30.200.20 1.10.510.10

2gfs

P38 kinase crystal structure in complex with ro3201195

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

2ghl

Mutant mus musculus p38 kinase domain in complex with inhibitor pg- 874743

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

2ghm

Mutated map kinase p38 (mus musculus) in complex with inhbitor pg- 895449

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

2gmx

Selective aminopyridine-based c-jun n-terminal kinase inhibitors with cellular activity

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the sequence is found naturally in homo sapiens (human)

Chains: A, B (358 residues) CATH domains: 3.30.200.20 1.10.510.10

2gph

Docking motif interactions in the map kinase erk2

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: erk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans.

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

2gtm

Mutated mouse p38 map kinase domain in complex with inhibitor pg- 892579

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

2gtn

Mutated map kinase p38 (mus musculus) in complex with inhbitor pg- 951717

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

2h96

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamidE C-jun nh2-terminal kinase inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the sequence is found naturally in homo sapiens (human).

Chains: A, B (359 residues) CATH domains: 3.30.200.20 1.10.510.10

2i0h

The structure of p38alpha in complex with an arylpyridazinone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

2lgc

Joint nmr and x-ray refinement reveals the structure of a novel dibenzo[a,d]cycloheptenone inhibitor/p38 map kinase complex in solution

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (359 residues) CATH domains: 3.30.200.20 1.10.510.10

2no3

Novel 4-anilinopyrimidines as potent jnk1 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the sequence is found naturally in homo sapiens

Chains: A, B (357 residues) CATH domains: 3.30.200.20 1.10.510.10

2npq

A novel lipid binding site in the p38 alpha map kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

2o0u

Crystal structure of human jnk3 complexed with n-{3-cyano-6-[3-(1- piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}- 1-naphthalenecarboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

2o2u

Crystal structure of human jnk3 complexed with n-(3-cyano-4,5,6,7- tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (319 residues) CATH domains: 3.30.200.20 1.10.510.10

2ojg

Crystal structure of erk2 in complex with n,n-dimethyl-4-(4-phenyl-1h- pyrazol-3-yl)-1h-pyrrole-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

2oji

Crystal structure of erk2 in complex with n-benzyl-4-(4-(3- chlorophenyl)-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

2ojj

Crystal structure of erk2 in complex with (s)-n-(1-(3-chloro-4- fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1h-pyrazol-3-yl)- 1h-pyrrole-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

2ok1

Crystal structure of jnk3 bound to n-benzyl-4-(4-(3-chlorophenyl)-1h- pyrazol-3-yl)-1h-pyrrole-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

2okr

Crystal structure of the p38a-mapkap kinase 2 heterodimer

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: this sequence occurs naturally in homo sapiens (humans)

Chains: A, D (339 residues) CATH domains: 3.30.200.20 1.10.510.10

2onl

Crystal structure of the p38a-mapkap kinase 2 heterodimer

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mapkapk2.

Chains: A, B (338 residues) CATH domains: 3.30.200.20 1.10.510.10

2oza

Structure of p38alpha complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Mus musculus. House mouse. Organism_taxid: 10090.

Chain: B (340 residues) CATH domains: 3.30.200.20 1.10.510.10

2p33

Synthesis and sar of aminopyrimidines as novel c-jun n-terminal kinase (jnk) inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

2puu

Crystal structure of p38 complex with 1-(5-tert-butyl-2-p-tolyl-2h- pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1- yl]urea

Source: Mus musculus. Mouse. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

2qd9

P38 alpha map kinase inhibitor based on heterobicyclic scaffolds

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 de3.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

2r9s

C-jun n-terminal kinase 3 with 3,5-disubstituted quinoline inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B (328 residues) CATH domains: 3.30.200.20 1.10.510.10

2rg5

Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11b

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 de3.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

2rg6

Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11j

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 de3.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

2waj

Crystal structure of human jnk3 complexed with a 1-aryl-3,4- dihydroisoquinoline inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

2xrw

Linear binding motifs for jnk and for calcineurin antagonistically control the nuclear shuttling of nfat4

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss. Synthetic: yes. Organism_taxid: 9606

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 92.86% similar to enzyme product ADP

Het Group ANP is 92.86% similar to enzyme product ADP

2xs0

Linear binding motifs for jnk and for calcineurin antagonistically control the nuclear shuttling of nfat4

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss. Synthetic: yes. Organism_taxid: 9606

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

2y8o

Crystal structure of human p38alpha complexed with a mapk docking peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss. Synthetic: yes. Organism_taxid: 9606

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

2y9q

Crystal structure of human erk2 complexed with a mapk docking peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss. Synthetic: yes. Organism_taxid: 9606

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

2yis

Triazolopyridine inhibitors of p38 kinase.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

2yiw

Triazolopyridine inhibitors of p38 kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

2yix

Triazolopyridine inhibitors of p38

Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

2z7l

Unphosphorylated mitogen activated protein kinase erk2 in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin 2-yl]amino}phenyl) acetic acid

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

2zaz

Crystal structure of p38 in complex with 4-anilino quinoline inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

2zb0

Crystal structure of p38 in complex with biphenyl amide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

2zb1

Crystal structure of p38 in complex with biphenyl amide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

2zdt

Crystal structure of human jnk3 complexed with an isoquinolone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

2zdu

Crystal structure of human jnk3 complexed with an isoquinolone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

2zoq

Structural dissection of human mitogen-activated kinase erk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk3, erk1, prkm3. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (352 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group 5ID is 62.07% similar to enzyme product ADP

Het Group 5ID is 62.07% similar to enzyme product ADP

3bv2

Morpholino pyrrolotriazine p38 alpha map kinase inhibitor compound 30

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 de3.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3bv3

Morpholino pyrrolotriazine p38 alpha map kinase inhibitor compound 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 de3.

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

3bx5

P38 alpha map kinase complexed with bms-640994

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

3c5u

P38 alpha map kinase complexed with a benzothiazole based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 de3.

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

3c9w

Crystal structure of erk-2 with hypothemycin covalently bound

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: erk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (336 residues) CATH domains: 3.30.200.20 1.10.510.10

3cgf

Irak-4 inhibitors (part ii)- a structure based assessment of imidazo[1,2 a]pyridine binding

Source: Homo sapiens. Human. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

3cgo

Irak-4 inhibitors (part ii)- a structure based assessment of imidazo[1,2 a]pyridine binding

Source: Homo sapiens. Human. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3coi

Crystal structure of p38delta kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: hepg2. Gene: mapk13, prkm13, sapk4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

3ctq

Structure of map kinase p38 in complex with a 1-o-tolyl-1,2,3- triazole-4-carboxamide

Source: Homo sapiens. Man. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

3d7z

Crystal structure of p38 kinase in complex with a biphenyl amide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3d83

Crystal structure of p38 kinase in complex with a biphenyl amide inhibitor

Source: Homo sapiens. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3da6

Crystal structure of human jnk3 complexed with n-(3-methyl-4-(3-(2- (methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1h- benzo[d]imidazol-2-amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (328 residues) CATH domains: 3.30.200.20 1.10.510.10

3ds6

P38 complex with a phthalazine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B, C, D (343 residues) CATH domains: 3.30.200.20 1.10.510.10

3dt1

P38 complexed with a quinazoline inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (356 residues) CATH domains: 3.30.200.20 1.10.510.10

3e7o

Crystal structure of jnk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk9, jnk2, prkm9. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (342 residues) CATH domains: 3.30.200.20 1.10.510.10

3e92

Crystal structure of p38 kinase in complex with a biaryl amide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3e93

Crystal structure of p38 kinase in complex with a biaryl amide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3elj

Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3erk

The complex structure of the map kinase erk2/sb220025

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

3fc1

Crystal structure of p38 kinase bound to pyrimido-pyridazinone inhibitor

Source: Homo sapiens. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_variant: tn-368.

Chain: X (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3fi2

Crystal structure of jnk3 with amino-pyrazole inhibitor, sr-3451

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (328 residues) CATH domains: 3.30.200.20 1.10.510.10

3fi3

Crystal structure of jnk3 with indazole inhibitor, sr-3737

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3fi4

P38 kinase crystal structure in complex with ro4499

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

3fkl

P38 kinase crystal structure in complex with ro9552

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

3fkn

P38 kinase crystal structure in complex with ro7125

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

3fko

P38 kinase crystal structure in complex with ro3668

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

3fl4

P38 kinase crystal structure in complex with ro5634

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

3fln

P38 kinase crystal structure in complex with r1487

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: C (343 residues) CATH domains: 3.30.200.20 1.10.510.10

3flq

P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)- 2-((s)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3- d]pyrimidin

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

3fls

P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)- 2-((r)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3- d]pyrimidin-7-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

3flw

P38 kinase crystal structure in complex with pamapimod

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

3fly

P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)- 2-isopropylamino-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3flz

P38 kinase crystal structure in complex with 8-methyl-6-phenoxy-2- (tetrahydro-pyran-4-ylamino)-8h-pyrido[2,3-d]pyrimidin-7-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3fmh

P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)- 8-methyl-2-((r)-1-methyl-2-tetrazol-2-yl-ethylamino)-8h-pyrido[2,3- d]pyrimidin-7-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3fmj

P38 kinase crystal structure in complex with 4-(5-methyl-3-phenyl- isoxazol-4-yl)-pyrimidin-2-ylamine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

3fmk

P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)- 8-methyl-2-((s)-1-methyl-2-tetrazol-2-yl-ethylamino)-8h-pyrido[2,3- d]pyrimidin-7-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

3fml

P38 kinase crystal structure in complex with ro6224

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

3fmm

P38 kinase crystal structure in complex with ro6226

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

3fmn

P38 kinase crystal structure in complex with ro2530

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

3fsf

P38 kinase crystal structure in complex with 3-(2,6-dichloro-phenyl)- 7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1h- pyrimido[4,5-d]pyrimidin-2-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

3fsk

P38 kinase crystal structure in complex with ro6257

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

3fv8

Jnk3 bound to piperazine amide inhibitor, sr2774.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3g90

Jnk-3 bound to (z)-5-fluoro-1-((6-fluoro-4h-benzo[d][1,3]dioxin-8-yl) methyl)-3-(hydroxyimino)indolin-2-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: X (345 residues) CATH domains: 3.30.200.20 1.10.510.10

3g9l

Jnk3 bound to (z)-1-((6-fluoro-4h-benzo[d][1,3]dioxin-8-yl)methyl)-3- (hydroxyimino)-4-styrylindolin-2-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: X (336 residues) CATH domains: 3.30.200.20 1.10.510.10

3g9n

Jnk3 bound to (z)-1-((6-fluoro-4h-benzo[d][1,3]dioxin-8-yl)methyl)-3- (hydroxyimino)-4-phenylindolin-2-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

3gc7

The structure of p38alpha in complex with a dihydroquinazolinone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mk14-human, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3gc8

The structure of p38beta c162s in complex with a dihydroquinazolinone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk11, prkm11, sapk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3gc9

The structure of p38beta c119s, c162s in complex with a dihydroquinazolinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk11, prkm11, sapk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3gcp

Human p38 map kinase in complex with sb203580

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3gcq

Human p38 map kinase in complex with rl45

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3gcs

Human p38 map kinase in complex with sorafenib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3gcu

Human p38 map kinase in complex with rl48

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (339 residues) CATH domains: 3.30.200.20 1.10.510.10

3gcv

Human p38 map kinase in complex with rl62

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

3gfe

Crystal structure of p38a mitogen-activated protein kinase in complex with a pyrazolopyridinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

3gi3

Crystal structure of a n-phenyl-n'-naphthylurea analog in complex with p38 map kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

3gp0

Crystal structure of human mitogen activated protein kinase 11 (p38 beta) in complex with nilotinib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk11, prkm11, sapk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

3ha8

The complex structure of the map kinase p38/compound 14b

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, p38. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

3hec

P38 in complex with imatinib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

3heg

P38 in complex with sorafenib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

3hl7

Crystal structure of human p38alpha complexed with sd-0006

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, thp-1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

3hll

Crystal structure of human p38alpha complexed with ph-797804

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, thp-1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3hp2

Crystal structure of human p38alpha complexed with a pyridinone compound

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, thp-1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

3hp5

Crystal structure of human p38alpha complexed with a pyrimidopyridazinone compound

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, thp-1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

3hrb

P38 kinase crystal structure in complex with small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: the plasmid used is annotated as sareum proprietary

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

3hub

Human p38 map kinase in complex with scios-469

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3huc

Human p38 map kinase in complex with rl40

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3hv3

Human p38 map kinase in complex with rl49

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3hv4

Human p38 map kinase in complex with rl51

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (339 residues) CATH domains: 3.30.200.20 1.10.510.10

3hv5

Human p38 map kinase in complex with rl24

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (339 residues) CATH domains: 3.30.200.20 1.10.510.10

3hv6

Human p38 map kinase in complex with rl39

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3hv7

Human p38 map kinase in complex with rl38

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

3hvc

Crystal structure of human p38alpha map kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10

3i5z

Crystal structure of erk2 bound to (s)-n-(2-hydroxy-1-phenylethyl)-4- (5-methyl-2-(phenylamino)pyrimidin-4-yl)-1h-pyrrole-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3i60

Crystal structure of erk2 bound to (s)-4-(2-(2-chlorophenylamino)-5- methylpyrimidin-4-yl)-n-(2-hydroxy-1-phenylethyl)-1h-pyrrole-2- carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3iph

Crystal structure of p38 in complex with a biphenylamide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3itz

Crystal structure of p38a mitogen-activated protein kinase in complex with a pyrazolopyridazine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (357 residues) CATH domains: 3.30.200.20 1.10.510.10

3iw5

Human p38 map kinase in complex with an indole derivative

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

3iw6

Human p38 map kinase in complex with a benzylpiperazin-pyrrol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3iw7

Human p38 map kinase in complex with an imidazo-pyridine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3iw8

Structure of inactive human p38 map kinase in complex with a thiazole- urea

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3k3i

P38alpha bound to novel dgf-out compound pf-00215955

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, p38. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3k3j

P38alpha bound to novel dfg-out compound pf-00416121

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

3kf7

Crystal structure of human p38alpha complexed with a triazolopyrimidine compound

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, thp-1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3kq7

Structure of human p38alpha with n-[4-methyl-3-(6-{[2-(1- methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2- (morpholin-4-yl)pyridine-4-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

3kvx

Jnk3 bound to aminopyrimidine inhibitor, sr-3562

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

3l8s

Human p38 map kinase in complex with cp-547632

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3l8x

P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21 de3.

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

3lfa

Human p38 map kinase in complex with dasatinib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

3lfb

Human p38 map kinase in complex with rl98

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

3lfc

Human p38 map kinase in complex with rl99

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3lfd

Human p38 map kinase in complex with rl113

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3lfe

Human p38 map kinase in complex with rl116

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3lff

Human p38 map kinase in complex with rl166

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3lhj

Crystal structure of p38a mitogen-activated protein kinase in complex with a pyrazolopyridinone inhibitor.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

3mgy

Mutagenesis of p38 map kinase eshtablishes key roles of phe169 in function and structural dynamics and reveals a novel dfg-out state

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

3mh0

Mutagenesis of p38 map kinase eshtablishes key roles of phe169 in function and structural dynamics and reveals a novel dfg-out state

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3mh1

Mutagenesis of p38 map kinase establishes key roles of phe169 in function and structural dynamics and reveals a novel dfg-out state

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3mh2

Mutagenesis of p38 map kinase establishes key roles of phe169 in function and structural dynamics and reveals a novel dfg-out state

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

3mh3

Mutagenesis of p38 map kinase establishes key roles of phe169 in function and structural dynamics and reveals a novel dfg-out state

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3mpa

Conformational plasticity of p38 map kinase dfg motif mutants in response to inhibitor binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3mpt

Crystal structure of p38 kinase in complex with a pyrrole-2- carboxamide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3mvl

P38 alpha map kinase complexed with pyrrolotriazine inhibitor 7k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21 de3.

Chains: A, B (339 residues) CATH domains: 3.30.200.20 1.10.510.10

3mvm

P38 alpha map kinase complexed with pyrrolotriazine inhibitor 7v

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21 de3.

Chains: A, B (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3mw1

P38 kinase crystal structure in complex with small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

3new

P38-alpha complexed with compound 10

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3nie

Crystal structure of pf11_0147

Source: Plasmodium falciparum. Organism_taxid: 5833. Gene: map2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (369 residues) CATH domains: 3.30.200.20 1.10.510.10

3nnu

Crystal structure of p38 alpha in complex with dp1376

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

3nnv

Crystal structure of p38 alpha in complex with dp437

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

3nnw

Crystal structure of p38 alpha in complex with dp802

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3nnx

Crystal structure of phosphorylated p38 alpha in complex with dp802

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3npc

Crystal structure of jnk2 complexed with birb796

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk9, jnk2, prkm9. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chains: A, B (357 residues) CATH domains: 3.30.200.20 1.10.510.10

3nww

P38 alpha kinase complexed with a 2-aminothiazol-5-yl-pyrimidine based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21(de3).

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

3o17

Crystal structure of jnk1-alpha1 isoform

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk1, mapk8, prkm8, sapk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Mus musculus. Mouse.

Chains: A, B (357 residues) CATH domains: 3.30.200.20 1.10.510.10

3o2m

Crystal structure of jnk1-alpha1 isoform complex with a biaryl tetrazol (a-82118)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk1, mapk8, prkm8, sapk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Mus musculus. Mouse.

Chains: A, B (358 residues) CATH domains: 3.30.200.20 1.10.510.10

3o71

Crystal structure of erk2/dcc peptide complex

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in rats

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

3o8p

Conformational plasticity of p38 map kinase dfg motif mutants in response to inhibitor binding

Source: Homo sapiens. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

3o8t

Conformational plasticity of p38 map kinase dfg-motif mutants in response to inhibitor binding

Source: Homo sapiens. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3o8u

Conformational plasticity of p38 map kinase dfg motif mutants in response to inhibitor binding

Source: Homo sapiens. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3obg

Conformational plasticity of p38 map kinase dfg mutants in response to inhibitor binding

Source: Homo sapiens. Organism_taxid: 9606. Strain: rosetta. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3obj

Conformational plasticity of p38 map kinase dfg mutants in response to inhibitor binding

Source: Homo sapiens. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3oc1

Conformational plasticity of p38 map kinase dfg motif mutants in response to inhibitor binding

Source: Homo sapiens. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

3ocg

P38 alpha kinase complexed with a 5-amino-pyrazole based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21(de3).

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

3od6

Crystal structure of p38alpha y323t active mutant

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: X (344 residues) CATH domains: 3.30.200.20 1.10.510.10

3ody

Crystal structure of p38alpha y323q active mutant

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: X (321 residues) CATH domains: 3.30.200.20 1.10.510.10

3odz

Crystal structure of p38alpha y323r active mutant

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: X (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3oef

Crystal structure of y323f inactive mutant of p38alpha map kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: X (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3oht

Crystal structure of salmo salar p38alpha

Source: Salmo salar. Atlantic salmon. Organism_taxid: 8030. Gene: p38a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3oxi

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of jnk for the treatment of neurodegenerative diseases

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mapk8ip1. Expression_system_taxid: 562

Chain: A (322 residues) CATH domains: 3.30.200.20 1.10.510.10

3oy1

Highly selectivE C-jun n-terminal kinase (jnk) 2 and 3 inhibitors with in vitro cns-like pharmacokinetic properties

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

3oz6

Crystal structure of mapk from cryptosporidium parvum, cgd2_1960

Source: Cryptosporidium parvum iowa ii. Organism_taxid: 353152. Gene: cgd2_1960. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, B (343 residues) CATH domains: 3.30.200.20 1.10.510.10

3p4k

The third conformation of p38a map kinase observed in phosphorylated p38a and in solution

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide derived from mek3b

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

3p5k

P38 inhibitor-bound

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3p78

P38 inhibitor-bound

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3p79

P38 inhibitor-bound

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3p7a

P38 inhibitor-bound

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3p7b

P38 inhibitor-bound

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3p7c

P38 inhibitor-bound

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

3pg3

Human p38 map kinase in complex with rl182

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3ptg

Design and synthesis of a novel, orally efficacious tri-substituted thiophene based jnk inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

3py3

Crystal structure of phosphorylated p38alpha map kinase

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (357 residues) CATH domains: 3.30.200.20 1.10.510.10

3pze

Jnk1 in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3qud

Human p38 map kinase in complex with 2-amino-phenylamino-benzophenone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

3que

Human p38 map kinase in complex with skepinone-l

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

3qyw

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligand: Het Group 6PB is 41.94% similar to enzyme product ADP

3qyz

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group Z8B is 58.06% similar to enzyme product ADP

Het Group Z8B is 58.06% similar to enzyme product ADP

3r63

Structure of erk2 (spe) mutant (s246e)

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3rin

P38 kinase crystal structure in complex with small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: dh10b-r. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3roc

Crystal structure of human p38 alpha complexed with a pyrimidinone compound

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, thp-1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3rp9

Crystal structure of the apo mapk from toxoplasma gondii, 25.M01780 or tgme49_007820

Source: Toxoplasma gondii. Organism_taxid: 508771. Strain: me49. Gene: 25.M01780, tgme49_007820. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

3rtp

Design and synthesis of brain penetrant selective jnk inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3s3i

P38 kinase crystal structure in complex with small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3s4q

P38 alpha kinase complexed with a pyrazolo-triazine based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 de3.

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

3sa0

Complex of erk2 with norathyriol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (357 residues) CATH domains: 3.30.200.20 1.10.510.10

3tei

Crystal structure of human erk2 complexed with a mapk docking peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

3tg1

Crystal structure of p38alpha in complex with a mapk docking partner

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3tti

Crystal structure of jnk3 complexed with cc-930, an orally active anti-fibrotic jnk inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

3ttj

Crystal structure of jnk3 complexed with cc-359, a jnk inhibitor for the prevention of ischemia-reperfusion injury

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

3u8w

Crystal structure of p38a mitogen-activated protein kinase in complex with a triazolopyridazinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3uvp

Human p38 map kinase in complex with a benzamide substituted benzosuberone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

3uvq

Human p38 map kinase in complex with a dibenzosuberone derivative

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

3uvr

Human p38 map kinase in complex with km064

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3v3v

Structural and functional analysis of quercetagetin, a natural jnk1 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Mus musculus. Mouse.

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

3v6r

Discovery of potent and selective covalent inhibitors of jnk

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (350 residues) CATH domains: 3.30.200.20 1.10.510.10

3v6s

Discovery of potent and selective covalent inhibitors of jnk

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (349 residues) CATH domains: 3.30.200.20 1.10.510.10

3vud

Crystal structure of a cysteine-deficient mutant m1 in map kinase jnk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans.

Chain: A (355 residues) CATH domains: 3.30.200.20 1.10.510.10

3vug

Crystal structure of a cysteine-deficient mutant m2 in map kinase jnk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (356 residues) CATH domains: 3.30.200.20 1.10.510.10

3vuh

Crystal structure of a cysteine-deficient mutant m3 in map kinase jnk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (355 residues) CATH domains: 3.30.200.20 1.10.510.10

3vui

Crystal structure of a cysteine-deficient mutant m2 in map kinase jnk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (355 residues) CATH domains: 3.30.200.20 1.10.510.10

3vuk

Crystal structure of a cysteine-deficient mutant m5 in map kinase jnk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (355 residues) CATH domains: 3.30.200.20 1.10.510.10

3vul

Crystal structure of a cysteine-deficient mutant m1 in map kinase jnk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

3vum

Crystal structure of a cysteine-deficient mutant m7 in map kinase jnk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

3w55

The structure of erk2 in complex with fr148083

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

3zs5

Structural basis for kinase selectivity of three clinical p38alpha inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

3zsg

X-ray structure of p38alpha bound to tak-715

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

3zsh

X-ray structure of p38alpha bound to scio-469

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

3zsi

X-ray structure of p38alpha bound to vx-745

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

3zu7

Crystal structure of a designed selected ankyrin repeat protein in complex with the map kinase erk2

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic construct. Organism_taxid: 32630. Expression_system_taxid: 83333. Expression_system_variant: xl1-blue.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

3zuv

Crystal structure of a designed selected ankyrin repeat protein in complex with the phosphorylated map kinase erk2

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic construct. Organism_taxid: 32630. Expression_system_taxid: 83333. Expression_system_variant: xl1-blue.

Chains: A, C (359 residues) CATH domains: 3.30.200.20 1.10.510.10

3zya

Human p38 map kinase in complex with 2-amino-phenylamino- dibenzosuberone

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

4a9y

P38alpha map kinase bound to cmpd 8

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

4aa0

P38alpha map kinase bound to cmpd 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

4aa4

P38alpha map kinase bound to cmpd 22

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

4aa5

P38alpha map kinase bound to cmpd 33

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

4aac

P38alpha map kinase bound to cmpd 29

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

4awi

Human jnk1alpha kinase with 4-phenyl-7-azaindole ikk2 inhibitor.

Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

4b99

Crystal structure of mapk7 (erk5) with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

4dli

Human p38 map kinase in complex with rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

4dlj

Human p38 map kinase in complex with rl163

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

4e5a

The w197a mutant of p38a map kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: X (332 residues) CATH domains: 3.30.200.20 1.10.510.10

4e5b

Structure of p38a map kinase without bog

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (324 residues) CATH domains: 3.30.200.20 1.10.510.10

4e6a

P38a-pia23 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (324 residues) CATH domains: 3.30.200.20 1.10.510.10

4e6c

P38a-perifosine complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

4e73

Crystal structure of jnk1beta-jip in complex with an azaquinolone inhbitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Chain: A (318 residues) CATH domains: 3.30.200.20 1.10.510.10

4e8a

The crystal structure of p38a map kinase in complex with pia24

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10

4eh2

Human p38 map kinase in complex with np-f1 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4eh3

Human p38 map kinase in complex with np-f2 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4eh4

Human p38 map kinase in complex with np-f3 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4eh5

Human p38 map kinase in complex with np-f4 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

4eh6

Human p38 map kinase in complex with np-f5 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

4eh7

Human p38 map kinase in complex with np-f6 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4eh8

Human p38 map kinase in complex with np-f7 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

4eh9

Human p38 map kinase in complex with np-f11 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

4ehv

Human p38 map kinase in complex with np-f10 and rl87

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4erk

The complex structure of the map kinase erk2/olomoucine

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group OLO is 44.12% similar to enzyme product ADP

Het Group OLO is 44.12% similar to enzyme product ADP

4ewq

Human p38 alpha mapk in complex with a pyridazine based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

4eyj

Mapk13 complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk13, prkm13, sapk4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

4eym

Mapk13 complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk13, prkm13, sapk4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

4f9w

Human p38alpha mapk in complex with a novel and selective small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

4f9y

Human p38 alpha mapk in complex with a novel and selective small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4fa2

Human p38 alpha mitogen-activated kinase in complex with sb239063

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4fmq

Crystal structure of human erk2 complexed with a mapk docking peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthesized peptide

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

4fux

Crystal structure of the erk2 complexed with e75

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

4fuy

Crystal structure of the erk2 complexed with ek2

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv0

Crystal structure of the erk2 complexed with ek3

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv1

Crystal structure of the erk2 complexed with ek4

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv2

Crystal structure of the erk2 complexed with ek5

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv3

Crystal structure of the erk2 complexed with ek6

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv4

Crystal structure of the erk2 complexed with ek7

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv5

Crystal structure of the erk2 complexed with ek9

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv6

Crystal structure of the erk2 complexed with e57

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv7

Crystal structure of the erk2 complexed with e94

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv8

Crystal structure of the erk2 complexed with e63

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

4fv9

Crystal structure of the erk2 complexed with e71

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10

4g1w

Crystal structure of jnk1 in complex with jip1 peptide and 7-fluoro-3- [4-(2-hydroxy-ethanesulfonyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro- quinoline-2-carboxylic acid methyl ester

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, hcg_23734. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (322 residues) CATH domains: 3.30.200.20 1.10.510.10

4g6n

Crystal structure of the erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

4g6o

Crystal structure of the erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

4geo

P38a map kinase def-pocket penta mutant (m194a, l195a, h228a, i229a, y258a)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

4gsb

Monoclinic crystal form of the apo-erk2

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

4gt3

Atp-bound form of the erk2 kinase

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

4gva

Adp-bound form of the erk2 kinase

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

4h36

Crystal structure of jnk3 in complex with atf2 peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: atf2, creb2, crebp1. Expression_system_taxid: 562

Chain: A (353 residues) CATH domains: 3.30.200.20 1.10.510.10

4h39

Crystal structure of jnk3 in complex with jip1 peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

4h3b

Crystal structure of jnk3 in complex with sab peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (351 residues) CATH domains: 3.30.200.20 1.10.510.10

4h3p

Crystal structure of human erk2 complexed with a mapk docking peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic construct

Chains: A, D (342 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

4h3q

Crystal structure of human erk2 complexed with a mapk docking peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic construct

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

4hys

Crystal structure of jnk1 in complex with jip1 peptide and 4-(4- indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, hcg_23734. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemical synthesis

Chain: A (321 residues) CATH domains: 3.30.200.20 1.10.510.10

4hyu

Crystal structure of jnk1 in complex with jip1 peptide and 4-{4-[4-(3- methanesulfonyl-propoxy)-indazol-1-yl]-pyrimidin-2-ylamino}- cyclohexan

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, hcg_23734. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemical synthesis

Chain: A (322 residues) CATH domains: 3.30.200.20 1.10.510.10

4i5h

Crystal structure of a double mutant rat erk2 complexed with a type ii quinazoline inhibitor

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: erk2, mapk, mapk1, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

4ic7

Crystal structure of the erk5 kinase domain in complex with an mkk5 binding fragment

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: map2k5, mek5, mkk5, prkmk5. Expression_system_taxid: 562

Chains: A, D (355 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

4ic8

Crystal structure of the apo erk5 kinase domain

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (325 residues) CATH domains: 3.30.200.20 1.10.510.10

4iz5

Structure of the complex between erk2 phosphomimetic mutant and pea-15

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: pea15.

Chains: A, B, C, D (347 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

4iz7

Structure of non-phosphorylated erk2 bound to the pea-15 death effector domain

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Cricetulus griseus. Chinese hamsters. Organism_taxid: 10029.

Chains: C, A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

4iza

Structure of dually phosphorylated erk2 bound to the pea-15 death effector domain

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: pea15.

Chains: A, C (348 residues) CATH domains: 3.30.200.20 1.10.510.10

4izy

Crystal structure of jnk1 in complex with jip1 peptide and 4-{4-[4-(4- methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}- cyclohexan

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, hcg_23734. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemical synthesis

Chain: A (322 residues) CATH domains: 3.30.200.20 1.10.510.10

4ka3

Structure of map kinase in complex with a docking peptide

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

4kin

Crystal structure of mitogen-activated protein kinase 14 (p38-h5) complex with 5-(2-chlorophenyl)-n-(5-(cyclopropylcarbamoyl)-2- methylphenyl)-2-thiophenecarboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21 de3.

Chains: A, B, C, D (338 residues) CATH domains: 3.30.200.20 1.10.510.10

4kip

Crystal structure of mitogen-activated protein kinase 14 (p38-h5) complex with 2-(2-chlorophenyl)-n-(5-(cyclopropylcarbamoyl)-2- methylphenyl)-1,3-thiazole-5-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 de3.

Chains: A, B (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4kiq

Crystal structure of mitogen-activated protein kinase 14 (p38-h5) complex with ethyl 6-((5-(cyclopropylcarbamoyl)-2-methylphenyl) carbamoyl)-1h-indole-1-carboxylate

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21 de3.

Chains: A, B, C, D (338 residues) CATH domains: 3.30.200.20 1.10.510.10

4kke

The crystal structure of amp-bound jnk3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (354 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group AMP is 85.19% similar to enzyme product ADP

Het Group AMP is 85.19% similar to enzyme product ADP

4kkg

Crystal structure of apo and amp-bound jnk3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (353 residues) CATH domains: 3.30.200.20 1.10.510.10

4kkh

The crystal structure of inhibitor-bound jnk3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

4l7f

Co-crystal structure of jnk1 and ax13587

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c

Chain: A (354 residues) CATH domains: 3.30.200.20 1.10.510.10

4l8m

Human p38 map kinase in complex with a dibenzoxepinone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4loo

Structural basis of autoactivation of p38 alpha induced by tab1 (monoclinic crystal form)

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

4lop

Structural basis of autoactivation of p38 alpha induced by tab1 (tetragonal crystal form)

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide

Chains: A, B, C, D (351 residues) CATH domains: 3.30.200.20 1.10.510.10

4loq

Structural basis of autoactivation of p38 alpha induced by tab1 (tetragonal crystal form with bound sulphate)

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide

Chains: A, B, C, D (352 residues) CATH domains: 3.30.200.20 1.10.510.10

4myg

Mapk13, active form

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk13, prkm13, sapk4. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chains: A, B (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4n0s

Complex of erk2 with caffeic acid

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (352 residues) CATH domains: 3.30.200.20 1.10.510.10

4n4s

A double mutant rat erk2 in complex with a pyrazolo[3,4-d]pyrimidine inhibitor

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: erk2, mapk, mapk1, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chains: A, B (342 residues) CATH domains: 3.30.200.20 1.10.510.10

4nif

Heterodimeric structure of erk2 and rsk1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rps6ka1, mapkapk1a, rsk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mapk1, erk2, prkm1, prkm2. Expression_system_taxid: 562

Chains: B, E (349 residues) CATH domains: 3.30.200.20 1.10.510.10

4o2z

Crystal structure of mpk3 from leishmania donovani, ldbpk_100540 in the presence of nvp-bbt594

Source: Leishmania donovani. Organism_taxid: 981087. Strain: bpk282a1. Gene: ldbpk_100540. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (363 residues) CATH domains: 3.30.200.20 1.10.510.10

4o6e

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (328 residues) CATH domains: 3.30.200.20 1.10.510.10

4qp1

Crystal structure of erk2 in complex with n-cyclohexyl-9h-purin-6- amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (343 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group EMU is 51.72% similar to enzyme product ADP

Het Group EMU is 51.72% similar to enzyme product ADP

4qp2

Crystal structure of erks in complex with 5-chlorobenzo[d]oxazol-2- amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4qp3

Crystal structure of erk2 in complex with (s)-2-((9h-purin-6-yl) amino)-3-phenylpropan-1-ol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (340 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group 36Q is 46.88% similar to enzyme product ADP

Het Group 36Q is 46.88% similar to enzyme product ADP

4qp4

Crystal structure of erk2 in complex with n-cyclohexyl-9h-purin-6- amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (337 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group 36O is 53.57% similar to enzyme product ADP

Het Group 36O is 53.57% similar to enzyme product ADP

4qp6

Crystal structure of erk2 in complex with 5h-pyrrolo[2,3-b]pyrazine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (340 residues) CATH domains: 3.30.200.20 1.10.510.10

4qp7

Crystal structure of erk2 in complex with 2-(1h-pyrazol-4-yl)-5h- pyrrolo[2,3-b]pyrazine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4qp8

Crystal structure of erk2 in complex with 2-(1h-pyrazol-4-yl)-7- (pyridin-3-yl)-5h-pyrrolo[2,3-b]pyrazine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (335 residues) CATH domains: 3.30.200.20 1.10.510.10

4qp9

Crystal structure of erk2 in complex with 7-(1-propyl-1h-pyrazol-4- yl)-2-(pyridin-4-yl)-5h-pyrrolo[2,3-b]pyrazine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

4qpa

Crystal structure of erk2 in complex with 7-(1-benzyl-1h-pyrazol-4- yl)-2-(pyridin-4-yl)-5h-pyrrolo[2,3-b]pyrazine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (332 residues) CATH domains: 3.30.200.20 1.10.510.10

4qta

Structure of human erk2 in complex with sch772984 revealing a novel inhibitor-induced binding pocket

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

4qtb

Structure of human erk1 in complex with sch772984 revealing a novel inhibitor-induced binding pocket

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erk1, mapk3, prkm3. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, B (351 residues) CATH domains: 3.30.200.20 1.10.510.10

4qtd

Structure of human jnk1 in complex with sch772984 and the amppnp- hydrolysed triphosphate revealing the second type-i binding mode

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk1, mapk8, prkm8, sapk1, sapk1c. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chain: A (355 residues) CATH domains: 3.30.200.20 1.10.510.10

4qte

Structure of erk2 in complex with vtx-11e, 4-{2-[(2-chloro-4- fluorophenyl)amino]-5-methylpyrimidin-4-yl}-n-[(1s)-1-(3- chlorophenyl)-2-hydroxyethyl]-1h-pyrrole-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

4qyy

Discovery of novel, dual mechanism erk inhibitors by affinity selection screening of an inactive kinase state

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4r3c

Crystal structure of p38 alpha map kinase in complex with a novel isoform selective drug candidate

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

4s2z

Erk2 intrinsically active mutant r65s

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

4s30

Erk2 intrinsically active mutant (i84a)

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

4s31

Crystal structure of mitogen-activated protein kinase 1 wterk2 at 1.45a

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

4s32

Crystal structure of erk2 amp-pnp complex

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 85.19% similar to enzyme product ADP

Het Group ANP is 85.19% similar to enzyme product ADP

4s33

Erk2 r65s mutant complexed with amp-pnp

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 92.86% similar to enzyme product ADP

Het Group ANP is 92.86% similar to enzyme product ADP

4s34

Erk2 (i84a) in complex with amp-pnp

Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

4tyh

Ternary complex of p38 and mk2 with a p38 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.

Chain: B (335 residues) CATH domains: 3.30.200.20 1.10.510.10

4u79

Crystal structure of human jnk3 in complex with a benzenesulfonamide inhibitor.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (337 residues) CATH domains: 3.30.200.20 1.10.510.10

4ux9

Crystal structure of jnk1 bound to a mkk7 docking motif

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Chains: A, B, C, D (343 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

4w4v

Jnk2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1h- pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

4w4w

Jnk2/3 in complex with n-(2-methylpyridin-4-yl)-3-{4- [(phenylcarbamoyl)amino]-1h-pyrazol-1-yl}benzamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

4w4x

Jnk2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1h- pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

4w4y

Jnk2/3 in complex with 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1h- pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

4whz

Design and synthesis of highly potent and isoform selective jnk3 inhibitors: sar studies on aminopyrazole derivatives

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

4x21

The map kinase jnk3 as target for halogen bonding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B (336 residues) CATH domains: 3.30.200.20 1.10.510.10

4xj0

Crystal structure of erk2 in complex with an inhibitor 14k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (346 residues) CATH domains: 3.30.200.20 1.10.510.10

4xne

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

4xoy

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

4xoz

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

4xp0

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

4xp2

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4xp3

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

4xrj

Crystal structure of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

4xrl

Crystal structure at room temperature of erk2 in complex with an inhibitor

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

4y46

Pyridopyrimidinone derivatives as potent and selectivE C-jun n- terminal kinase (jnk) inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

4y5h

Pyridopyrimidinone derivatives as potent and selectivE C-jun n- terminal kinase (jnk) inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10

4yno

Crystal structure of mapk13 at inactive form

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk13, prkm13, sapk4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

4yr8

Crystal structure of jnk in complex with a regulator protein

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: dusp16, kiaa1700, mkp7.

Chains: E, A, C, F (317 residues) CATH domains: 3.30.200.20 1.10.510.10

4z9l

The structure of jnk3 in complex with an imidazole-pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (333 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

4zsg

Mitogen activated protein kinase 7 in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

4zsj

Mitogen activated protein kinase 7 in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

4zsl

Mitogen activated protein kinase 7 in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

4zth

Structure of human p38amapk-arylpyridazinylpyridine fragment complex used in inhibitor discovery

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4zxt

Complex of erk2 with catechol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (351 residues) CATH domains: 3.30.200.20 1.10.510.10

4zzm

Human erk2 in complex with an irreversible inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

4zzn

Human erk2 in complex with an inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4zzo

Human erk2 in complex with an irreversible inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

5awm

The crystal structure of jnk from drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian jnk proteins.

Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: bsk, jnk, cg5680. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

5ax3

Crystal structure of erk2 complexed with allosteric and atp- competitive inhibitors.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group 5ID is 62.07% similar to enzyme product ADP

Het Group 5ID is 62.07% similar to enzyme product ADP

5bue

Erk2 complexed with n-benzylpyridone tetrahydroazaindazole

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

5bui

Erk2 complexed with 2-pyridiyl tetrahydroazaindazole

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

5buj

Erk2 complexed with a n-h tetrahydroazaindazole

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

5bvd

Tetrahydropyrrolo-diazepenones as inhibitors of erk2 kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

5bve

Tetrahydropyrrolo-diazepenones as inhibitors of erk2 kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

5bvf

Tetrahydropyrrolo-diazepenones as inhibitors of erk2 kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10

5byy

Erk5 in complex with small molecule

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

5byz

Erk5 in complex with small molecule

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (348 residues) CATH domains: 3.30.200.20 1.10.510.10

5ci6

Crystal structure of arabidopsis thaliana mpk6

Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: mpk6, at2g43790, f18o19.10. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B (335 residues) CATH domains: 3.30.200.20 1.10.510.10

5ekn

Crystal structure of mapk13 complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk13, prkm13, sapk4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

5eko

Crystal structure of mapk13 complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk13, prkm13, sapk4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (341 residues) CATH domains: 3.30.200.20 1.10.510.10

5eta

Structure of mapk14 with bound the kim domain of the toxoplasma protein gra24

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Toxoplasma gondii. Organism_taxid: 5811

Chains: B, A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

5etc

Structure of inactive mapk14 with ordered activation loop

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (355 residues) CATH domains: 3.30.200.20 1.10.510.10

5etf

Structure of dead kinase mapk14 with bound the kim domain of mkk6

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (338 residues) CATH domains: 3.30.200.20 1.10.510.10

5eti

Structure of dead kinase mapk14

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (355 residues) CATH domains: 3.30.200.20 1.10.510.10

5ez0

Crystal structure of the ptpn4 pdz domain complexed with the pdz binding motif of the mitogen activated protein kinase p38gamma.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Chains: G, H (11 residues)

5hd4

Dissecting therapeutic resistance to erk inhibition rat wild type sch772984 in complex with (3r)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl) phenyl]piperazin-1-yl}ethyl)-n-[3-(pyridin-4-yl)-2h-indazol-5- yl]pyrrolidine-3-carboxamide

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

5hd7

Dissecting therapeutic resistance to erk inhibition rat mutant sch772984 in complex with (3r)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl) phenyl]piperazin-1-yl}ethyl)-n-[3-(pyridin-4-yl)-2h-indazol-5- yl]pyrrolidine-3-carboxamide

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

5k4i

Crystal structure of erk2 in complex with compound 22

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

5ke0

Discovery of 1-1h-pyrazolo 4,3-c pyridine-6-yl urea inhibitors of extracellular signal regulated kinase erk for the treatment of cancers

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (340 residues) CATH domains: 3.30.200.20 1.10.510.10

5lar

Crystal structure of p38 alpha mapk14 in complex with vpc00628

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2

Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10

5lcj

In-gel activity-based protein profiling of a clickable covalent erk 1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10

5lck

A clickable covalent erk 1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (347 residues) CATH domains: 3.30.200.20 1.10.510.10

5lw1

Crystal structure of darpin-darpin rigid fusion, variant dd_232_11_d12 in complex jnk1a1 and jip1 peptide

Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: xl1-blue. Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c.

Chains: B, E, H (355 residues)

Bound ligands: Het Group ADN is 70.37% similar to enzyme product ADP

Het Group ADN is 70.37% similar to enzyme product ADP

5ml5

Human p38alpha mapk in complex with imidazolyl pyridine inhibitor 11b

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (326 residues)

5mtx

Dibenzooxepinone inhibitor 12b in complex with p38 mapk

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (331 residues)

5mty

Dibenzosuberone inhibitor 8e in complex with p38 mapk

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (328 residues)

5mz3

P38 alpha mutant c162s in complex with cmpd2 [n-(4-methyl-3-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(trifluoromethyl) benzamide]

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (350 residues)

5n63

Crystal structure of p38alpha in complex with lipid pocket ligand 9c

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (325 residues)

5n64

Crystal structure of p38alpha in complex with lipid pocket ligand 9g

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (329 residues)

5n65

Crystal structure of p38alpha in complex with lipid pocket ligand 9h

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (333 residues)

5n66

Crystal structure of p38alpha in complex with lipid pocket ligand 9j

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues)

5n67

Crystal structure of p38alpha in complex with lipid pocket ligand 9l

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (327 residues)

5n68

Crystal structure of p38alpha in complex with lipid pocket ligand 9m

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (328 residues)

5ngu

Human erk2 with an erk1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues)

5nhf

Human erk2 with an erk1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues)

5nhh

Human erk2 with an erk1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5nhj

Human erk2 with an erk1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5nhl

Human erk2 with an erk1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5nho

Human erk2 with an erk1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues)

5nhp

Human erk2 with an erk1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (338 residues)

5nhv

Human erk2 with an erk1/2 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5nzz

Crystal structure of phosphorylated p38amapk in complex with tab1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tab1, map3k7ip1. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.

Chains: E, F, G, H (345 residues)

Bound ligand: Het Group AGS is 93.75% similar to enzyme reactant ATP

5o7i

Erk5 in complex with a pyrrole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (340 residues)

5o8u

Covalent inhibitor 4b bound to the lipid pocket of p38alpha mutant s252c

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (331 residues)

5o8v

Covalent inhibitor 4a bound to the lipid pocket of p38alpha mutant s251c

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (328 residues)

5o90

Crystal structure of a p38alpha t185g mutant in complex with tab1 peptide.

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta 2. Synthetic: yes. Homo sapiens.

Chain: A (330 residues)

5omg

P38alpha in complex with pyrazolobenzothiazine inhibitor coxp4m12

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (337 residues)

5omh

P38alpha in complex with pyrazolobenzothiazine inhibitor coxh11

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (325 residues)

5r8u

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n05703b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

5r8v

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n09139b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

5r8w

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment k00283c in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r8x

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n11396a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r8y

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n08078b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

5r8z

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n01381c in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r90

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n11145a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues)

5r91

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment kcl057 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

5r92

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment kcl063 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5r93

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment kcl077 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r94

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment kcl081 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

5r95

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment kcl093 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

5r96

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment kcl095 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

5r97

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13662a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r98

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n14109a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r99

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13619a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

5r9a

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13838a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

Bound ligands: Het Group SQM is 40.62% similar to enzyme product ADP

Het Group SQM is 40.62% similar to enzyme product ADP

5r9b

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13866a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues)

5r9c

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n14074a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

Bound ligands: Het Group 7ZC is 40.00% similar to enzyme product ADP

Het Group 7ZC is 40.00% similar to enzyme product ADP

5r9d

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment s00888c in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

5r9e

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13693a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5r9f

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13724a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5r9g

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment pc587 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

Bound ligands: Het Group RGY is 41.94% similar to enzyme product ADP

Het Group RGY is 41.94% similar to enzyme product ADP

5r9h

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment tcj658 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

5r9i

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment tcj795 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (337 residues)

5r9j

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n14231a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

5r9k

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n14246a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues)

5r9l

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n14274a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues)

5r9m

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13418a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues)

5r9n

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13421a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues)

5r9o

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n06122b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r9p

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13430a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r9q

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n07422b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

5r9r

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13413a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r9s

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13470a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r9t

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13477a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

Bound ligands: Het Group 6T5 is 40.62% similar to enzyme product ADP

Het Group 6T5 is 40.62% similar to enzyme product ADP

5r9u

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13475a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5r9v

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13596a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r9w

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13598a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5r9x

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13611a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

5r9y

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13619a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues)

5r9z

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13502a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5ra0

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n13421a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5ra1

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n08141b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5ra2

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n09036b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

Bound ligands: Het Group SV4 is 41.38% similar to enzyme product ADP

Het Group SV4 is 41.38% similar to enzyme product ADP

5ra3

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n10836b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

5ra4

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n11337a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5ra5

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n11302a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5ra6

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n11338a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5ra7

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n11351a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5ra8

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n05711b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

5ra9

Pandda analysis group deposition form1 map kinase p38-alpha -- fragment n08051b in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

5tbe

Human p38alpha map kinase in complex with dibenzosuberone compound 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues)

5tco

Human p38 map kinase in complex with dibenzosuberone compound 1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (327 residues)

5u6i

Discovery of mli-2, an orally available and selective lrrk2 inhibitor that reduces brain kinase activity

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues)

5umo

Structure of extracellular signal-regulated kinase

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (347 residues)

5uoj

The structure of the map kinase p38 at 2.1 angstroms resolution

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (343 residues)

5v60

Phospho-erk2 bound to amp-pcp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (349 residues)

Bound ligands: Het Group ACP is 81.25% similar to enzyme product ADP

Het Group ACP is 81.25% similar to enzyme product ADP

5v61

Phospho-erk2 bound to bivalent inhibitor sbp2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens, HIV-1 m:b_hxb2r. Human, HIV-1.

Chain: A (350 residues)

5v62

Phospho-erk2 bound to bivalent inhibitor sbp3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chain: A (351 residues)

5wjj

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 map kinase inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590.

Chain: A (338 residues)

5wp1

Complex of erk2 with 5,7-dihydroxychromone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (343 residues)

5xyx

The structure of p38 alpha in complex with a triazol inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (337 residues)

5xyy

The structure of p38 alpha in complex with a triazol inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues)

5z33

Crystal structure of mitogen-activated protein kinase mps1 in magnaporthe oryzae

Source: Magnaporthe oryzae (strain p131). Rice blast fungus. Organism_taxid: 1143193. Strain: p131. Gene: mps1. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768

Chain: A (375 residues)

6anl

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 map kinase inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590.

Chain: A (338 residues)

6cpw

Discovery of 3(s)-thiomethyl pyrrolidine erk inhibitors for oncology

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (328 residues)

6d5y

Crystal structure of erk2 g169d mutant

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (337 residues)

6dcg

Discovery of mk-8353: an orally bioavailable dual mechanism erk inhibitor for oncology

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (326 residues)

6dmg

A multiconformer ligand model of ek6 bound to erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

6dtl

Mitogen-activated protein kinase 6

Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: mpk6, at2g43790, f18o19.10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (356 residues)

6ekd

Crystal structure of jnk3 in complex with a pyridinylimidazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (325 residues)

6emh

Crystal structure of jnk3 in complex with a pyridinylimidazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B, C, D (344 residues)

6eq9

Crystal structure of jnk3 in complex with amp-pcp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (350 residues)

Bound ligands: Het Group ACP is 81.25% similar to enzyme product ADP

Het Group ACP is 81.25% similar to enzyme product ADP

6f5e

Crystal structure of darpin-darpin rigid fusion, variant dd_d12_10_47 in complex jnk1a1 and jip1 peptide

Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: xl1-blue. Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c.

Chain: B (346 residues)

6fi3

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues)

Bound ligands: Het Group DJ2 is 67.86% similar to enzyme product ADP

Het Group DJ2 is 67.86% similar to enzyme product ADP

6fi6

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues)

Bound ligands: Het Group DF8 is 65.52% similar to enzyme product ADP

Het Group DF8 is 65.52% similar to enzyme product ADP

6fj0

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues)

Bound ligands: Het Group A3N is 58.06% similar to enzyme product ADP

Het Group A3N is 58.06% similar to enzyme product ADP

6fjb

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (338 residues)

Bound ligands: Het Group AOC is 63.33% similar to enzyme product ADP

Het Group AOC is 63.33% similar to enzyme product ADP

6fjz

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

Bound ligands: Het Group DKW is 61.29% similar to enzyme product ADP

Het Group DKW is 61.29% similar to enzyme product ADP

6fle

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues)

Bound ligands: Het Group DQ2 is 46.15% similar to enzyme product ADP

Het Group DQ2 is 46.15% similar to enzyme product ADP

6flv

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

Bound ligands: Het Group DTW is 47.37% similar to enzyme product ADP

Het Group DTW is 47.37% similar to enzyme product ADP

6fma

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues)

Bound ligands: Het Group DU8 is 50.00% similar to enzyme product ADP

Het Group DU8 is 50.00% similar to enzyme product ADP

6fn5

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (336 residues)

Bound ligands: Het Group DVZ is 51.43% similar to enzyme product ADP

Het Group DVZ is 51.43% similar to enzyme product ADP

6fq7

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues)

Bound ligands: Het Group E2K is 48.65% similar to enzyme product ADP

Het Group E2K is 48.65% similar to enzyme product ADP

6fr1

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues)

Bound ligands: Het Group E3K is 47.37% similar to enzyme product ADP

Het Group E3K is 47.37% similar to enzyme product ADP

6frp

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (340 residues)

Bound ligands: Het Group ZAS is 60.00% similar to enzyme product ADP

Het Group ZAS is 60.00% similar to enzyme product ADP

6fxv

Crystal structure of erk2 in complex with an adenosine derivative

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (337 residues)

Bound ligands: Het Group E9W is 47.37% similar to enzyme product ADP

Het Group E9W is 47.37% similar to enzyme product ADP

6g54

Crystal structure of erk2 covalently bound to sm1-71

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: r3.

Chain: A (347 residues)

6g8x

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (339 residues)

6g91

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (345 residues)

6g92

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chain: A (344 residues)

Bound ligands: Het Group ERZ is 40.00% similar to enzyme product ADP

Het Group ERZ is 40.00% similar to enzyme product ADP

6g93

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (344 residues)

6g97

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (345 residues)

6g9a

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (342 residues)

6g9d

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (346 residues)

6g9h

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chain: A (344 residues)

6g9j

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (350 residues)

6g9k

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (345 residues)

6g9m

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (342 residues)

6g9n

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (345 residues)

6gdm

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (345 residues)

6gdq

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (340 residues)

6ge0

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (345 residues)

6ges

Crystal structure of erk1 covalently bound to sm1-71

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk3, erk1, prkm3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.

Chains: A, B (350 residues)

6gjb

Erk2 signalling protein

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (348 residues)

6gjd

Erk2 signalling protein

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: de3

Chain: A (342 residues)

6hkm

Crystal structure of compound 1 with erk5

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (327 residues)

6hkn

Crystal structure of compound 35 with erk5

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk7, bmk1, erk5, prkm7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (333 residues)

6hwt

Crystal structure of p38alpha in complex with a reduced photoswitchable 2-azothiazol-based inhibitor (compound 31)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (336 residues)

6hwu

Crystal structure of p38alpha in complex with a photoswitchable 2- azothiazol-based inhibitor (compound 2)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (333 residues)

6hwv

Crystal structure of p38alpha in complex with a photoswitchable 2- azoimidazol-based inhibitor (compound 3)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (336 residues)

6m95

Structure-based design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine-2-one based p38 map kinase inhibitors by scaffold hopping: compound 1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469

Chain: A (333 residues)

6m9l

Structure-based design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine-2-one based p38 map kinase inhibitors by scaffold hopping - compound 10

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469

Chain: A (331 residues)

6nbs

Wt erk2 with compound 2507-8

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues)

6ohd

P38 in complex with t-3220137

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469

Chain: A (330 residues)

6opg

Phosphorylated erk2 with amp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (349 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

6oph

Phosphorylated erk2 with gdc-0994

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

6opi

Phosphorylated erk2 with sch-cpd336

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (326 residues)

6opk

Phosphorylated erk2 with vertex-11e

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

6ot6

Rat erk2 d319n

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Expression_system_variant: rosetta ii

Chain: A (346 residues)

6ots

Rat erk2 e320k

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Expression_system_variant: rosetta ii

Chain: A (324 residues)

6q7k

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (346 residues)

Bound ligand: Het Group 2AI is 41.67% similar to enzyme reactant protein

6q7s

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (342 residues)

6q7t

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (340 residues)

6qa1

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (342 residues)

6qa3

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (342 residues)

6qa4

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (337 residues)

Bound ligand: Het Group HRZ is 50.00% similar to enzyme reactant protein

6qag

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (340 residues)

6qah

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (340 residues)

6qal

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (336 residues)

6qaq

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (344 residues)

6qaw

Erk2 mini-fragment binding

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (338 residues)

Bound ligand: Het Group HVE is 41.94% similar to enzyme product ADP

6qdz

P38 alpha complex with ar117045

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: gold plyss ag

Chain: A (327 residues)

6qe1

P38 alpha complex with ar117046

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: gold plyss ag

Chain: A (328 residues)

6qyx

P38(alpha) map kinase with the activation loop of erk2

Source: Homo sapiens, crassostrea ariakensis. Human, suminoe oyster. Organism_taxid: 9606, 94323. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (339 residues)

6rfo

Erk2 map kinase with the activation loop of p38alpha

Source: Rattus norvegicus, homo sapiens. Norway rat, human. Organism_taxid: 10116, 9606. Gene: mapk1, erk2, mapk, prkm1, mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (316 residues)

6rfp

Erk2 map kinase with mutations at helix-g

Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (337 residues)

6rq4

Inhibitor of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues)

6sfi

Crystal structure of p38 alpha in complex with compound 75 (mcp33)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (340 residues)

6sfj

Crystal structure of p38 alpha in complex with compound 77 (mcp41)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (341 residues)

6sfk

Crystal structure of p38 alpha in complex with compound 81 (mcp42)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (339 residues)

6sfo

Mapk14 with bound inhibitor sr-318

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (334 residues)

6slg

Human erk2 with erk1/2 inhibitor, azd0364.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chain: A (332 residues)

6so1

Fragment n13569a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues)

6so2

Fragment n13460a in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

6so4

Fragment rz132 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues)

6sod

Fragment n14056a in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

6soi

Fragment n13788a in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

6sot

Fragment n11290a in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues)

6sou

Fragment n13565a in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (342 residues)

6sov

Fragments kcl_615 and kcl_802 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

6sp9

Fragment kcl802 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

6spl

Fragment kcl615 in complex with map kinase p38-alpha

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

6tca

Phosphorylated p38 and mapkapk2 complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expression_system_taxid: 562

Chains: B, D, F, H (346 residues)

6una

Crystal structure of inactive p38gamma

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk12, erk6, sapk3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta

Chains: A, B (329 residues)

6v6a

Inhibitory scaffolding of the ancient mapk, erk7

Source: Toxoplasma gondii. Organism_taxid: 383379. Strain: rh. Gene: mapk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: tggt1_246950. Expression_system_taxid: 469008

Chains: A, C (317 residues)

6y4t

Crystal structure of p38 in complex with sr63.

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (341 residues)

6y4u

Crystal structure of p38 in complex with sr65

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (341 residues)

6y4v

Crystal structure of p38 in complex with sr68

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (343 residues)

6y4w

Crystal structure of p38 in complex with sr69

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (341 residues)

6y4x

Crystal structure of p38 in complex with sr72

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (351 residues)

6y6v

P38a bound with mcp-81

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (331 residues)

6y7w

Fragment kcl_1337 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

6y7x

Fragment kcl_771 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

6y7y

Fragments kcl_771 and kcl_802 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (343 residues)

6y7z

Fragment kcl_914 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

6y80

Fragment kcl_916 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

6y81

Fragment kcl_1088 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

6y82

Fragment kcl_804 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

6y85

Fragment kcl_1410 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

6y8h

Novel p38-alpha crystal lattice with highly exposed p38/tab1 non- canonical ppi surface.

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

6ycu

Fragment kcl_k777 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

6ycw

Fragment kcl_k767 in complex with map kinase p38-alpha

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

6yjc

Crystal structure of p38alpha in complex with sr154

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (337 residues)

6yk7

Crystal structure of p38 in complex with sr43

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (341 residues)

6yky

Biochemical, cellular and structural characterization of novel erk3 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk6, erk3, prkm6. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B, C, D (281 residues)

6ylc

Biochemical, cellular and structural characterization of novel erk3 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk6, erk3, prkm6. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B, C, D (282 residues)

6yll

Biochemical, cellular and structural characterization of novel erk3 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk6, erk3, prkm6. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (293 residues)

6zqs

Crystal structure of double-phosphorylated p38alpha with atf2(83-102)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss. Synthetic: yes. Organism_taxid: 9606

Chain: A (350 residues)

6zr5

Crystal structure of jnk1 in complex with atf2(19-58)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss. Gene: atf2, creb2, crebp1.

Chains: A, B (348 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

6zwp

P38a bound with sr348

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (328 residues)

6zwr

P38a bound with sr92

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (338 residues)

7aqb

Crystal structure of human mitogen activated protein kinase 6 (mapk6)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk6, erk3, prkm6. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chains: A, B (294 residues)

7auv

The structure of erk2 in complex with dual inhibitor astx029

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (347 residues)

7bdo

Mapk14 bound with sr302

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (332 residues)

7bdq

Mapk14 bound with sr300

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (336 residues)

7be4

Crystal structure of map kinase p38 alpha in complex with inhibitor sr159

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (331 residues)

7be5

Crystal structure of map kinase p38 alpha in complex with inhibitor sr276

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (329 residues)

7cga

Crystal structure of human unphosphorylated p38gamma

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk12, erk6, sapk3. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B, C, D (347 residues)

7cml

The crystal structure of human jnk2 from biortus.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk9, jnk2, prkm9, sapk1a. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (334 residues)

7e73

Crystal structure of human erk2 mutant (y36h)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

7e75

Crystal structure of human erk2 mutant (g37c)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (349 residues)

7ksi

Thiophenyl-pyrazolourea derivatives as potent, brian penetrant, orally bioavailable, and isoform-selective jnk3 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

7ksj

Thiophenyl-pyrazolourea derivatives as potent, brian penetrant, orally bioavailable, and isoform-selective jnk3 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

7ksk

Thiophenyl-pyrazolourea derivatives as potent, brian penetrant, orally bioavailable, and isoform-selective jnk3 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (334 residues)

7n8t

Crystal structure of amp-bound human jnk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk9, jnk2, prkm9, sapk1a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (355 residues)

Bound ligands: Het Group AMP is 85.19% similar to enzyme product ADP

Het Group AMP is 85.19% similar to enzyme product ADP

7nqq

Discovery of astx029, a clinical candidate which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (342 residues)

7nqw

Discovery of astx029, a clinical candidate which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (346 residues)

7nr3

Discovery of astx029, a clinical candidate which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (337 residues)

7nr5

Discovery of astx029, a clinical candidate which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768.

Chain: A (342 residues)

7nr8

Discovery of astx029, a clinical candidate which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (346 residues)

7nr9

Discovery of astx029, a clinical candidate which modulates the phosphorylation and catalytic activity of erk1/2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (335 residues)

7opm

Phosphorylated erk2 in complex with orf45

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630.

Chain: A (362 residues)

7ore

Crystal structure of jnk3 in complex with light-activated covalent inhibitor mr-ii-249 with both non-covalent and covalent binding modes (compound 4)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (352 residues)

7orf

Crystal structure of jnk3 in complex with fmu-001-367 (compound 1)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Chain: A (351 residues)

7pus

Erk5 in complex with pyrrole carboxamide scaffold

Source: Homo sapiens

Chain: A (340 residues)

7pvu

Crystal structure of p38alpha c162s in complex with cas2094511-69-8, p 1 21 1

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (337 residues)

7qiy

Specific features and methylation sites of a plant ribosome. 40s head ribosomal subunit.

Source: Solanum lycopersicum. Tomato. Organism_taxid: 4081. Organism_taxid: 4081

Chain: O (317 residues)

7s1n

N-aromatic-substituted indazole derivatives as brain penetrant and orally bioavailable jnk3 inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

7ugb

Crystal structure of rat erk2 complexed with docking peptide from isg20

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Homo sapiens. Human.

Chain: A (333 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

7w5c

Crystal structure of mitogen activated protein kinase 4 (mpk4) from arabidopsis thaliana

Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: mpk4, at4g01370, f2n1.1, f2n1_2-t. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Synthetic: yes. Organism_taxid: 3702

Chain: A (355 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

7w5o

Crystal structure of erk2 with an allosteric inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Chains: A, B (350 residues)

Bound ligands: Het Group 5ID is 62.07% similar to enzyme product ADP

Het Group 5ID is 62.07% similar to enzyme product ADP

7x4u

Crystal structure of erk2 with an allosteric inhibitor 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chain: A (350 residues)

Bound ligands: Het Group 5ID is 62.07% similar to enzyme product ADP

Het Group 5ID is 62.07% similar to enzyme product ADP

7xc1

Crystal structure of erk2 with an allosteric inhibitor 3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chains: A, B (351 residues)

Bound ligands: Het Group 5ID is 62.07% similar to enzyme product ADP

Het Group 5ID is 62.07% similar to enzyme product ADP

7yl1

Crystal structure of jnk3 in complex with a fragment molecule

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (352 residues)

8a8m

Structure of the mapk p38alpha in complex with its activating map2k mkk6

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: map2k6, mek6, mkk6, prkmk6, skk3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (349 residues)

Bound ligands: Het Group AP2 is 68.75% similar to enzyme product ADP

Het Group AP2 is 68.75% similar to enzyme product ADP

8ao2

Specific covalent inhibitor (3) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (341 residues)

8ao3

Specific covalent inhibitor of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (339 residues)

8ao4

Specific covalent inhibitor (5) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (339 residues)

8ao5

Specific covalent inhibitor (6) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (330 residues)

8ao6

Electrophilic inhibitor (7) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (338 residues)

8ao7

Specific covalent inhibitor (8) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (346 residues)

8ao8

Specific covalent inhibitor(9) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (342 residues)

8ao9

Specific covalent inhibitor(10) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (338 residues)

8aoa

Covalent and non-covalent inhibitor of erk2 (two sites)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (346 residues)

8aob

Specific covalent inhibitor(12) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (321 residues)

8aoc

Specific covalent inhibitor of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (346 residues)

8aod

Specific covalent inhibitor(14) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (335 residues)

8aoe

Specific covalent inhibitor(15) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (337 residues)

8aof

Specific covalent inhibitor(16) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (341 residues)

8aog

Non-specific covalent inhibitor(17) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (337 residues)

8aoh

Specific covalent inhibitor(18) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (334 residues)

8aoi

Specific covalent inhibitor(19) of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (346 residues)

8aoj

Specific covalent inhibitor of erk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (340 residues)

8bzp

Jnk3 (mitogen-activated protein kinase 10) in complex with compound 23 bearing a c(sp3)f2br moiety

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chains: A, B (350 residues)

8efj

A structural study of selectivity mechanisms for jnk3 and p38 alpha with indazole scaffold probing compounds

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

8elc

Human jnk2 bound to covalent inhibitor yl2056

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk9, jnk2, prkm9, sapk1a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (355 residues)

8enj

Design, synthesis, biological evaluation, and x-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-jun n-terminal kinase (jnk)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (333 residues)

8h59

A fungal map kinase in complex with an inhibitor

Source: Pyricularia oryzae 70-15. Organism_taxid: 242507. Strain: 70-15. Gene: mps1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (375 residues)

8psr

Erk2 covalently bound to synthrevd-12-opt artificial peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630.

Chain: A (354 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8pst

Erk2 covelently bound to ru60 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (333 residues)

Bound ligands: Het Group AN2 is 92.86% similar to enzyme product ADP

Het Group AN2 is 92.86% similar to enzyme product ADP

8psw

Erk2 covalently bound to ru67 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (338 residues)

Bound ligands: Het Group AN2 is 92.86% similar to enzyme product ADP

Het Group AN2 is 92.86% similar to enzyme product ADP

8psy

Erk2 covelently bound to ru68 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (340 residues)

Bound ligands: Het Group AN2 is 92.86% similar to enzyme product ADP

Het Group AN2 is 92.86% similar to enzyme product ADP

8pt0

Erk2 covelently bound to ru75 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (348 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8pt1

Erk2 covelently bound to ru76 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (349 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8pt3

Erk2 covelently bound to ru77 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (344 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8pt5

Erk2 covelently bound to ru187 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (336 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8pt8

Jnk1 covalently bound to ru135 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B, C (353 residues)

8pt9

Jnk1 covalently bound to bd838 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chains: A, B, C (353 residues)

8pta

Jnk1 covalently bound to bd837 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B, C (354 residues)

8pvu

Cryo-em structure of dhs-erk2 complex with 1:1 stoichiometry refined in c1 symmetry

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: dhps, ds. Expression_system_taxid: 562

Chain: E (301 residues)

8qr2

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (340 residues)

8qr3

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (346 residues)

8qr4

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (340 residues)

8qr5

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (342 residues)

8qr6

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (346 residues)

8qr7

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (341 residues)

8qr8

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (342 residues)

8qr9

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (346 residues)

8qra

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (341 residues)

8qrb

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (348 residues)

8qrc

Crystal structure of erk2 in complex with a covalently bound macrocyclic ligand

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (337 residues)

8r5e

Jnk1 covalently bound to ru77 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (359 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8r5f

Erk2 covalently bound to ru83 cyclohexenone based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (337 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8rlx

Erk2 map kinase t188a mutant

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

8rm2

Erk2 map kinase t188e mutant

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

8rmb

Erk2 map kinase (r65s+t188d) double mutant

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (347 residues)

8rqv

Erk2 map kinase (t188a) amp-pnp complex

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8rqw

Erk2 map kinase (t188e) amp-pnp complex

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8rqx

Erk2 map kinase r65s+t188d - amp-pnp complex

Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (344 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8u8j

Co-crystal structure of phosphorylated erk2 in complex with erk1/2 inhibitor #16

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768

Chain: A (352 residues)

8u8k

Co-crystal structure of phosphorylated erk2 in complex with erk1/2 inhibitor #8

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768

Chain: A (349 residues)

8vnx

A structural study of selectivity mechanisms for jnk3 and p38 alpha with indazole scaffold probing compounds

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

8vo4

A structural study of selectivity mechanisms for jnk3 and p38 alpha with indazole scaffold probing compounds

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (346 residues)

8vt6

A structural study of selectivity mechanisms for jnk3 and p38 alpha with indazole scaffold probing compounds

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

8vwm

A structural study of selectivity mechanisms for jnk3 and p38 alpha with indazole scaffold probing compounds

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (348 residues)

8wgf

The crystal structure of jnk3 from biortus.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

8x23

The crystal structure of mapk13 from biortus.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk13. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (345 residues)

8x3m

Crystal structure of p38alpha with an allosteric inhibitor 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chain: A (350 residues)

8x5m

The crystal structure of jnk1 from biortus.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (341 residues)

8yd9

Crystal structure of p38alpha with an allosteric inhibitor 3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chain: A (350 residues)

8ygw

The crystal structure of mapk11 from biortus

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk11, prkm11, sapk2, sapk2b. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (326 residues)

8yp8

Structure of the p38alpha-pepheptpm(16-31)(v31c ) complex

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Human.

Chain: A (343 residues)

8ype

The crystal structure of inactive p38 complexed with a atf2 from 46 to 80

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: atf2, creb2, crebp1. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090.

Chain: A (344 residues)

8ypf

The crystal structure of inactive p38 complexed with a atf2 from 46 to 90

Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.

Chain: A (336 residues)

8zjv

Crystal structure of the erk2 complexed with 5-iodotubercidin

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (349 residues)

Bound ligands: Het Group 5ID is 62.07% similar to enzyme product ADP

Het Group 5ID is 62.07% similar to enzyme product ADP

8ztc

Crystal structure of mps1-amp complex

Source: Pyricularia oryzae. Organism_taxid: 318829. Gene: mps1, pgni_01373. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (371 residues)

Bound ligands: Het Group AMP is 85.19% similar to enzyme product ADP

Het Group AMP is 85.19% similar to enzyme product ADP

9cj1

Dual phosphorylated human p38 alpha bound to nilotinib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chain: A (331 residues)

9cj2

Dual phosphorylated human p38 alpha

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chains: A, B (347 residues)

9cj4

Dual phosphorylated human p38 alpha bound to birb796

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chain: A (336 residues)

9ft9

Structure of the bipartite jnk1-jip1 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk8, jnk1, prkm8, sapk1, sapk1c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: mapk8ip1, ib1, jip1, prkm8ip. Expression_system_taxid: 469008

Chain: A (357 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP